双核芳基金属钌三硫代配合物高效催化半胱氨酸和谷胱甘肽的氧化。
Efficient oxidation of cysteine and glutathione catalyzed by a dinuclear areneruthenium trithiolato anticancer complex.
机构信息
Departement für Chemie und Biochemie, Universität Bern, CH-3012 Bern, Switzerland.
出版信息
Inorg Chem. 2011 Nov 7;50(21):10552-4. doi: 10.1021/ic201941j. Epub 2011 Oct 7.
PMID:21981265
Abstract
The highly cytotoxic diruthenium complex (p-MeC(6)H(4)Pr(i))(2)Ru(2)(SC(6)H(4)-p-Me)(3) (1), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of the thiols cysteine and glutathione to give the corresponding disulfides, which may explain its high in vitro anticancer activity.
摘要
高细胞毒性双钌配合物(p-MeC(6)H(4)Pr(i))(2)Ru(2)(SC(6)H(4)-p-Me)(3) (1)，以氯化物盐的形式具有水溶性，被证明能有效地催化半胱氨酸和谷胱甘肽的硫醇氧化为相应的二硫化物，这可能解释了其高体外抗癌活性。
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