Male Sexual & Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
J Sex Med. 2012 Jan;9(1):302-8. doi: 10.1111/j.1743-6109.2011.02502.x. Epub 2011 Oct 7.
Peyronie's disease (PD) is commonly seen in middle-aged men, and little is known about this condition in teenagers.
To investigate the characteristics of PD in teenagers.
The findings were compared between patients with the disease who were teenagers with those over 40 years of age. Statistical analyses were conducted to define differentiating features between these two groups.
The demographics, clinical features, and associated comorbidities of patients with PD were reviewed.
Thirty-two teenaged males were evaluated for PD in a single institution over a 10-year period. The median age for our cohort was 18 (15-19) years. Forty-five percent of patients had already been seen by another urologist, and 28% had been told they did not have PD. The mean duration of PD before seeking medical care in our cohort was 3 ± 1 months. Sixteen percent of patients reported antecedent penile trauma, half of which happened during coitus or masturbation, and 18% of patients had hemoglobin (Hb) A1c levels > 5%. Dupuytren's contracture was not seen in this population. Twenty-two percent of patients presented with penile pain. Subsequent ED was seen in 37% of patients. Multiple noncontiguous plaques were seen in 37% of patients. Twelve percent were previously treated with vitamin E, while another 12% had previous intralesional verapamil. High distress was reported by 94% of patients. Thirty-four percent sought medical attention for anxiety/mood disorder, and 28% had a negative encounter with a sexual partner related to PD. All of the 32 patients had penile curvature with a mean of 32 ± 12 degrees. Seventy-two percent of the patients had dorsal curvature while 22% had an associated deformity. Using duplex Doppler ultrasound, 12% had a calcified plaque, while none of the patients had abnormal hemodynamics. When compared with PD in adults, teenagers had greater than seven times the prevalence of multiple noncontiguous plaques (37% vs. 5%). Also, the prevalence of HbA1c level > 5% was higher in the teenagers as well (18% vs. 5%).
PD does occur in teenagers often causing high distress levels. Compared to older adults, teenagers often present earlier, and more commonly have elevated HbA1c level and increased number of plaques at presentation.
佩罗尼氏病（PD）常见于中年男性，而青少年中的这种疾病则知之甚少。
研究青少年 PD 的特征。
比较了在一家医院接受治疗的青少年 PD 患者与年龄超过 40 岁的患者的发现。进行了统计分析以确定这两组之间的区别特征。
回顾了 PD 患者的人口统计学、临床特征和相关合并症。
在一家机构的 10 年期间，评估了 32 名青少年男性的 PD。队列的中位年龄为 18 岁（15-19 岁）。45%的患者已经看过另一位泌尿科医生，28%的患者被告知他们没有 PD。在我们的队列中，寻求医疗护理之前 PD 的平均持续时间为 3±1 个月。16%的患者报告有阴茎创伤史，其中一半发生在性交或自慰期间，18%的患者血红蛋白（Hb）A1c 水平>5%。该人群中未发现掌挛缩症。22%的患者出现阴茎疼痛。随后有 37%的患者出现 ED。37%的患者有多个不连续的斑块。12%的患者以前接受过维生素 E 治疗，另有 12%的患者接受过局部维拉帕米治疗。94%的患者报告有高度的痛苦。34%的患者因焦虑/情绪障碍寻求医疗帮助，28%的患者因 PD 与性伴侣发生负面接触。所有 32 名患者均有阴茎弯曲，平均弯曲度为 32±12 度。72%的患者有背侧弯曲，而 22%的患者有相关畸形。使用双功多普勒超声，12%的患者有钙化斑块，而无患者有异常血液动力学。与成人 PD 相比，青少年 PD 的多发性不连续斑块的患病率高出 7 倍（37%比 5%）。此外，青少年的 HbA1c 水平>5%的患病率也更高（18%比 5%）。
PD 确实会发生在青少年中，经常导致高度的痛苦水平。与老年患者相比，青少年患者往往更早出现，并且在就诊时更常见 HbA1c 水平升高和斑块数量增加。
