氨基甲酸酯类农药急性中毒：克里特岛的经验

Acute poisoning with carbamate pesticides: the Cretan experience.

作者信息

Tsatsakis A M, Tsakalof A K, Siatitsas Y, Michalodimitrakis E N

机构信息

Toxicology Unit, University of Crete, Heraklion, Greece.

出版信息

Sci Justice. 1996 Jan-Mar;36(1):35-9. doi: 10.1016/S1355-0306(96)72552-2.

DOI:10.1016/S1355-0306(96)72552-2

PMID:8612054

Abstract

In Crete, in southern Greece, a number of fatal carbamate poisonings were investigated over a period of 2 years, from 1991 to 1993. Five cases are reported, involving the fatal ingestion of methomyl (Lannate), a cholinesterase-inhibiting carbamate insecticide. Analysis of samples of blood plasma and serum showed more than 90% inhibition of cholinesterase. The blood methomyl concentrations had a mean value of 26.7 mg/l, and a range of 5.6-57.0 mg/l. These values are much higher than those previously reporter in similar cases (0.57-1.4 mg/l). Methomyl concentrations in organs and tissues were found to be significantly lower than those in blood and vitreous humour.

摘要

在希腊南部的克里特岛，1991年至1993年的两年间对多起致命的氨基甲酸酯中毒事件进行了调查。报告了5起病例，均因摄入灭多威（万灵）这一抑制胆碱酯酶的氨基甲酸酯类杀虫剂而致死。血浆和血清样本分析显示胆碱酯酶抑制率超过90%。血液中灭多威浓度的平均值为26.7毫克/升，范围在5.6至57.0毫克/升之间。这些数值远高于此前类似病例报告中的数值（0.57至1.4毫克/升）。发现器官和组织中的灭多威浓度显著低于血液和玻璃体液中的浓度。