在使用前列腺素E2进行宫颈成熟过程中脐动脉多普勒血流速度波形及母体前列腺素E2和F2α代谢物浓度

Umbilical artery Doppler flow velocity waveforms and maternal prostaglandin E2 and F2 alpha metabolite concentrations during cervical ripening with prostaglandin E2.

作者信息

Fairlie F M, Lang G D, Greer I A, McLaren M

机构信息

Glasgow Royal Maternity Hospital, Department of Obstetrics & Gynaecology, Leicester Royal Infirmary, U.K.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1990 Oct;37(1):7-13. doi: 10.1016/0028-2243(90)90089-j.

DOI:10.1016/0028-2243(90)90089-j

PMID:2198178

Abstract

In 20 women, the umbilical artery flow velocity waveform (FVW) was recorded immediately before and 30-40 min after administering vaginal or extraamniotic prostaglandin E2 to ripen the cervix. Maternal plasma concentrations of prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) metabolites (bicyclo-PGEM and PGFM, respectively) were measured at the time of the Doppler recordings. The administration of prostaglandin E2 was associated with a significant rise in maternal plasma PGFM and bicyclo-PGEM concentrations, but there was no change in the umbilical artery FVW Pulsatility index (PI). These results suggest that cervical ripening with local prostaglandin E2 has no effect on the umbilical artery FVW.

摘要

在20名女性中，于经阴道或羊膜外给予前列腺素E2以促进宫颈成熟之前及给药后30 - 40分钟，记录脐动脉血流速度波形（FVW）。在进行多普勒记录时，测量母体血浆中前列腺素E2（PGE2）和前列腺素F2α（PGF2α）代谢物（分别为双环-PGEM和PGFM）的浓度。给予前列腺素E2与母体血浆PGFM和双环-PGEM浓度显著升高相关，但脐动脉FVW搏动指数（PI）无变化。这些结果表明，局部应用前列腺素E2促进宫颈成熟对脐动脉FVW无影响。