Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Eur J Med Chem. 2011 Nov;46(11):5487-97. doi: 10.1016/j.ejmech.2011.09.011. Epub 2011 Sep 16.
Here in, we report the design, synthesis, and antibacterial activity of series of bulky arenesulfonamido derivatives using ciprofloxacin and norfloxacin as scaffolds. All the synthesized compounds were investigated in vitro for their antibacterial activities against two Gram-positive and two Gram-negative organisms using dilution broth method. Among the tested compounds examined, compounds 3-7 showed significance difference from the standard drug ciprofloxacin. 2D-QSAR study provides details on the fine relationship linking structure and activity and offers clues for structural modifications that can improve the activity. Docking study of the compound 3b into the active site of the topoisomerase II DNA-gyrase enzymes revealed a similar binding mode to ciprofloxacin with additional classical and nonclassical hydrogen bonds.
在这里，我们报告了一系列使用环丙沙星和诺氟沙星作为支架的大芳烃磺酰胺衍生物的设计、合成和抗菌活性。所有合成的化合物都通过稀释肉汤法在体外对两种革兰氏阳性菌和两种革兰氏阴性菌进行了抗菌活性测试。在所测试的化合物中，化合物 3-7 与标准药物环丙沙星相比有显著差异。2D-QSAR 研究提供了关于结构与活性之间精细关系的详细信息，并为可以提高活性的结构修饰提供了线索。化合物 3b 与拓扑异构酶 II DNA-gyrase 酶的活性位点对接研究表明，其结合模式与环丙沙星相似，具有额外的经典和非经典氢键。
