Sposato Bruno, Scalese Macro
Unità di Pneumologia, Ospedale "Misericordia", Grosseto, Italy.
CNR, Istituto di Fisiologia Clinica, Pisa, Italy.
Allergol Immunopathol (Madr). 2013 Jan-Feb;41(1):17-24. doi: 10.1016/j.aller.2011.08.001. Epub 2011 Oct 5.
The aim was to evaluate the impact of Cupressus sempervirens (Cs) and Juniperus communis (Jc) sensitisations in "Maremma" in southern Tuscany.
811 consecutive outpatients (357 F - 57.86%; age: 36.9 ± 16.6) with suspected allergic respiratory symptoms underwent skin prick tests (SPT) for common allergens and for Cs and Jc.
SPT resulted negative in 295 (36.37%) subjects. A Cs/Jc sensitisation was found in 294 (36.25%): 289 (98.3%) were sensitised to Cs whereas 198 (67.34%) to Jc. There was a co-sensitisation between Cs and Jc in 193 (65.6%) subjects. Cs/Jc mono-sensitisation was found in 39 (13.6%) subjects. A higher number (p<0.0001) of Cs/Jc sensitised subjects reported winter (131-44.55%) and spring (124-42.2%) symptoms compared to Cs/Jc non-sensitised and non-allergic subjects. Most Cs/Jc sensitised subjects reported rhinitis and conjunctivitis (p<0.0001), whereas only few reported coughing and asthma (p<0.01). The most frequent co-sensitisation was with grass, olive and other trees in Cs/Jc subjects (p<0.001). Those who reported winter symptoms, likely influenced by Cupressaceae, rhinitis was the main symptom whereas asthma was less frequent. Cs/Jc sensitisation resulted to be a risk factor (OR: 1.73 [CI95% 1.18-2.55]) for rhinitis whereas the probability of being asthmatic was reduced (OR: 0.62 [CI95% 0.44-0.85]).
The prevalence of Cs/Jc sensitisation is about 36% in "Maremma". However, only in 44% of the patients, Cs/Jc seem to cause typical winter symptoms. Rhinitis is the predominant symptom, whereas asthma is less frequent. Testing Cupressaceae sensitisation using Jc pollen extract, rather than Cs, may result to be less sensitive.
评估托斯卡纳南部“马雷马”地区意大利柏木（Cs）和刺柏（Jc）致敏的影响。
811例连续的疑似过敏性呼吸道症状门诊患者（357例女性，占57.86%；年龄：36.9±16.6岁）接受了常见变应原以及Cs和Jc的皮肤点刺试验（SPT）。
295例（36.37%）受试者的SPT结果为阴性。294例（36.25%）发现有Cs/Jc致敏：289例（98.3%）对Cs致敏，而198例（67.34%）对Jc致敏。193例（65.6%）受试者存在Cs和Jc的共同致敏。39例（13.6%）受试者发现有Cs/Jc单一致敏。与未致敏和非过敏的Cs/Jc受试者相比，Cs/Jc致敏受试者中报告冬季（131例，占44.55%）和春季（124例，占42.2%）症状的人数更多（p<0.0001）。大多数Cs/Jc致敏受试者报告有鼻炎和结膜炎（p<0.0001），而只有少数报告有咳嗽和哮喘（p<0.01）。Cs/Jc受试者中最常见的共同致敏是对草、橄榄和其他树木（p<0.001）。那些报告有冬季症状的人，可能受柏科植物影响，鼻炎是主要症状，而哮喘较少见。Cs/Jc致敏是鼻炎的一个危险因素（比值比：1.73[95%置信区间1.18 - 2.55]），而患哮喘的概率降低（比值比：0.62[95%置信区间0.44 - 0.85]）。
在“马雷马”地区，Cs/Jc致敏的患病率约为36%。然而，仅44%的患者中，Cs/Jc似乎会引发典型的冬季症状。鼻炎是主要症状，而哮喘较少见。使用Jc花粉提取物而非Cs检测柏科植物致敏可能敏感性较低。
