Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Immunity. 2011 Oct 28;35(4):562-71. doi: 10.1016/j.immuni.2011.07.013. Epub 2011 Oct 6.
The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that mast cell-derived interleukin-2 (IL-2) contributes to the suppression of chronic allergic dermatitis. Mice deficient in IL-2 production, or deficient in mast cells (Kit(W-sh/W-sh)), showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type counterparts. Adoptive transfer of wild-type, but not Il2(-/-), mast cells into Kit(W-sh/W-sh) mice dampened the inflammatory response. During the course of disease, mast cell expansion occurred at the site of inflammation and also in the spleen, where production of IL-2 by mast cells was markedly enhanced. In the absence of mast cell IL-2 production, the ratio of activated to regulatory T cells at the site of inflammation was increased. Thus, MC-derived IL-2 contributes to the maintenance of suppression in chronic allergic skin inflammation.
慢性过敏性皮炎的发病率正在迅速上升。对此疾病的调控控制尚未得到充分探索。在这里，我们报告称，肥大细胞衍生的白细胞介素 2（IL-2）有助于抑制慢性过敏性皮炎。与野生型相比，缺乏 IL-2 产生或缺乏肥大细胞（Kit(W-sh/W-sh)）的小鼠在反复氧化唑酮挑战时表现出加重的皮炎。将野生型但不是 Il2(-/-)肥大细胞过继转移到 Kit(W-sh/W-sh)小鼠中可减轻炎症反应。在疾病过程中，肥大细胞在炎症部位和脾脏中扩张，其中肥大细胞产生的 IL-2 明显增强。在缺乏肥大细胞 IL-2 产生的情况下，炎症部位激活的 T 细胞与调节性 T 细胞的比值增加。因此，MC 衍生的 IL-2 有助于维持慢性过敏性皮肤炎症的抑制。
