Service d'Histologie-Embryologie-Biologie de la Reproduction, CECOS, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France.
Fertil Steril. 2011 Dec;96(6):1320-1324.e1. doi: 10.1016/j.fertnstert.2011.08.025. Epub 2011 Oct 7.
To report the level of leukocytospermia in fertile donors' semen. Surprisingly, seminal leukocytes protect fertilization properties of sperm and are associated with normal or improved assisted reproductive technology outcomes in infertility patients. This raises the question of whether leukocytospermia exists in fertile men as well. We report a study of sperm donors who, by law in France, have to be of proven fertility.
Retrospective analysis.
University laboratory.
PATIENT(S): One hundred fifty-five donors were selected for cryobanking. Results of their sperm analyses were compared with those from 10,242 infertile men.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): The men's first ejaculate was studied by cytologic analysis to determine the round cell and polymorphonuclear cell (PMN) contents. A total of 3,875 donor sperm inseminations (DSIs) were performed, and their outcomes were analyzed over an 8-year period.
RESULT(S): PMN is more elevated in semen from infertility patients than in semen from fertile donors, but some donors (6.5%) had high leukocytospermia (≥10(6)/mL). The post-DSI pregnancy rate was increased when round cells were present (P<.02) but not with higher PMN concentrations. Furthermore, high leukocytospermia was associated with an increased post-DSI miscarriage rate.
CONCLUSION(S): In fertile donors, as in infertility patients, high leukocytospermia (>10(6)/mL) is associated with a normal pregnancy rate but an increased percentage of early pregnancy loss.
报告生育力正常供精者精液中白细胞精子的水平。令人惊讶的是，精液中的白细胞可以保护精子的受精能力，并与不孕患者的正常或改善的辅助生殖技术结局相关。这就提出了一个问题，即生育力正常的男性是否也存在白细胞精子症。我们报告了一项对精子供者的研究，根据法国法律，这些供者必须具有可证实的生育力。
回顾性分析。
大学实验室。
选择了 155 名供者进行冷冻库保存。比较了他们的精子分析结果与 10242 名不育男性的结果。
无。
通过细胞学分析研究男性的首次精液，以确定圆细胞和多形核白细胞（PMN）的含量。共进行了 3875 次供精人工授精（DSI），并在 8 年内分析了其结局。
PMN 在不育患者的精液中比在生育力正常供者的精液中更高，但有些供者（6.5%）存在白细胞精子症（≥10^6/ml）。当存在圆细胞时，DSI 后的妊娠率增加（P<.02），但PMN浓度较高时则不然。此外，高白细胞精子症与 DSI 后流产率增加相关。
在生育力正常的供者中，与不育患者一样，高白细胞精子症（>10^6/ml）与正常妊娠率相关，但早期妊娠丢失的百分比增加。
