Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 42121 Modena, Italy.
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, 41125 Modena, Italy.
Int J Mol Sci. 2021 Mar 4;22(5):2584. doi: 10.3390/ijms22052584.
Endothelial dysfunction is an early event in the pathogenesis of atherosclerosis and represents the first step in the pathogenesis of cardiovascular diseases. The evaluation of endothelial health is fundamental in clinical practice and several direct and indirect markers have been suggested so far to identify any alterations in endothelial homeostasis. Alongside the known endothelial role on vascular health, several pieces of evidence have demonstrated that proper endothelial functioning plays a key role in human fertility and reproduction. Therefore, this state-of-the-art review updates the endothelial health markers discriminating between those available for clinical practice or for research purposes and their application in human fertility. Moreover, new molecules potentially helpful to clarify the link between endothelial and reproductive health are evaluated herein.
内皮功能障碍是动脉粥样硬化发病机制中的早期事件，代表了心血管疾病发病机制的第一步。内皮健康的评估在临床实践中至关重要，迄今为止已经提出了几种直接和间接的标志物来识别内皮内稳态的任何改变。除了已知的内皮对血管健康的作用外，还有一些证据表明，适当的内皮功能在人类生育和生殖中起着关键作用。因此，本综述更新了区分那些可用于临床实践或研究目的的内皮健康标志物及其在人类生育中的应用。此外，本文还评估了一些新的分子，这些分子可能有助于阐明内皮和生殖健康之间的联系。
