School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Fitoterapia. 2012 Jan;83(1):1-5. doi: 10.1016/j.fitote.2011.09.013. Epub 2011 Sep 24.
Previous studies revealed that diterpenoids from Callicarpa genus were mainly of clerodane-type and phyllocladane-type, and abietane-type diterpenoids were seldom reported. In this paper, we reported two new abietane diterpenoids, kochianic acid A (1) and kochianic acid B (2), together with two known abietane-type diterpenoids, pedunculatic acid B (3) and 7α, 15-dihydroxydehydroabietic acid (4), which were all isolated from Callicarpa kochiana. The structures of the new compounds 1 and 2 were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, ROESY and finally confirmed by single-crystal X-ray diffraction.
先前的研究表明，马缨丹属植物中的二萜类化合物主要为 clerodane 型和 phyllocladane 型，而 abietane 型二萜类化合物则很少有报道。在本文中，我们报道了从马缨丹中分离得到的两个新的 abietane 型二萜类化合物 Kochianic acid A (1) 和 Kochianic acid B (2)，以及两个已知的 abietane 型二萜类化合物 Pedunculatic acid B (3) 和 7α, 15-dihydroxydehydroabietic acid (4)。新化合物 1 和 2 的结构是通过广泛的光谱分析，包括 HSQC、HMBC、(1)H-(1)H COSY、ROESY 等手段确定的，并最终通过单晶 X 射线衍射得到证实。
