两种新的贝壳杉烷二萜类化合物来自于金叶女贞的茎和叶。
Two new abietane diterpenoids from the caulis and leaves of Callicarpa kochiana.
机构信息
School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
出版信息
Fitoterapia. 2012 Jan;83(1):1-5. doi: 10.1016/j.fitote.2011.09.013. Epub 2011 Sep 24.
Previous studies revealed that diterpenoids from Callicarpa genus were mainly of clerodane-type and phyllocladane-type, and abietane-type diterpenoids were seldom reported. In this paper, we reported two new abietane diterpenoids, kochianic acid A (1) and kochianic acid B (2), together with two known abietane-type diterpenoids, pedunculatic acid B (3) and 7α, 15-dihydroxydehydroabietic acid (4), which were all isolated from Callicarpa kochiana. The structures of the new compounds 1 and 2 were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, ROESY and finally confirmed by single-crystal X-ray diffraction.
先前的研究表明，马缨丹属植物中的二萜类化合物主要为 clerodane 型和 phyllocladane 型，而 abietane 型二萜类化合物则很少有报道。在本文中，我们报道了从马缨丹中分离得到的两个新的 abietane 型二萜类化合物 Kochianic acid A (1) 和 Kochianic acid B (2)，以及两个已知的 abietane 型二萜类化合物 Pedunculatic acid B (3) 和 7α, 15-dihydroxydehydroabietic acid (4)。新化合物 1 和 2 的结构是通过广泛的光谱分析，包括 HSQC、HMBC、(1)H-(1)H COSY、ROESY 等手段确定的，并最终通过单晶 X 射线衍射得到证实。
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