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A new synthetic methodology for preparing radioactive androgen receptor binding compounds in order to determine receptor-ligands interactions has been developed.

摘要

为了确定受体-配体相互作用，已开发出一种制备放射性雄激素受体结合化合物的新合成方法。

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本文引用的文献

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A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor.一种基于配体的方法来确定雄激素受体的定量构效关系。

J Med Chem. 2004 Jul 15;47(15):3765-76. doi: 10.1021/jm0499007.

2

Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators.代谢稳定的选择性雄激素受体调节剂的设计、合成及生物学特性研究

J Med Chem. 2004 Feb 12;47(4):993-8. doi: 10.1021/jm030336u.

3

Pharmacodynamics of selective androgen receptor modulators.选择性雄激素受体调节剂的药效学

用于成像研究的不可逆结合比卡鲁胺类似物的合成。

Synthesis of irreversibly binding bicalutamide analogs for imaging studies.

作者信息

Nair Vipin A, Mustafa Suni M, Mohler Michael L, Yang Jun, Kirkovsky Leonid I, Dalton James T, Miller Duane D

机构信息

Department of Pharmaceutical Sciences, University of Tennessee, The Health Science Center, 847 Monroe Avenue, RM 227 C, Memphis, TN 38163, USA.

出版信息

Tetrahedron Lett. 2005 Jul 11;46(28):4821-4823. doi: 10.1016/j.tetlet.2005.04.143.

DOI:10.1016/j.tetlet.2005.04.143

PMID:18079986

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2134918/

Abstract

A new synthetic methodology for preparing radioactive androgen receptor binding compounds in order to determine receptor-ligands interactions has been developed.

摘要

为了确定受体-配体相互作用，已开发出一种制备放射性雄激素受体结合化合物的新合成方法。