Université de Lyon, F-69622 Lyon, France.
Eur J Pharm Biopharm. 2012 Jan;80(1):235-9. doi: 10.1016/j.ejpb.2011.09.013. Epub 2011 Sep 29.
The encapsulation of hydrophobic drugs has been widely investigated using mainly oil phase in order to enhance the encapsulation efficiency. However, the effect of the starting materials on the colloidal properties of the final nanocapsules irrespective of the elaboration process has been neglected, and the hydrophobic drug location in the disperse media has not been completely elucidated. Therefore, this paper describes the effect of the oil used in the recipe and the preparation method on the behavior of nanocapsules prepared via nanoprecipitation and via emulsification-diffusion. The colloidal stability of the final dispersions, drug location and the drug release are preparation method dependent. In turn, the type of oil governs drug encapsulation efficiency regardless of the method and the size when nanocapsules are prepared by nanoprecipitation.
疏水药物的包封已广泛研究，主要使用油相以提高包封效率。然而，人们忽略了起始材料对最终纳米胶囊胶体性质的影响，且疏水药物在分散介质中的位置也未被完全阐明。因此，本文描述了配方中油的使用和制备方法对通过纳米沉淀和乳化-扩散法制备的纳米胶囊行为的影响。最终分散体的胶体稳定性、药物位置和药物释放与制备方法有关。反过来，无论纳米胶囊是通过纳米沉淀还是乳化-扩散法制备，油的类型都决定了药物的包封效率和纳米胶囊的粒径。
