Altun Burak, Acar Gürkan, Akçay Ahmet, Sökmen Abdullah, Kaya Hakan, Köroğlu Sedat
Department of Cardiology, Medicine Faculty of Sütçü İmam University, Kahramanmaraş, Turkey.
Turk Kardiyol Dern Ars. 2011 Oct;39(7):563-7. doi: 10.5543/tkda.2011.01585.
Hypertension is an important cardiovascular risk factor for the development of atrial fibrillation (AF). Increased atrial electromechanical coupling time interval measured by tissue Doppler is accepted as an important factor for prediction of AF development in hypertensive patients. The aim of this study was to compare the effects of valsartan, an angiotensin receptor blocker, and nebivolol, a beta-blocker, on atrial electromechanical coupling in newly diagnosed stage 1 hypertensive patients.
The study included 60 newly diagnosed stage 1 hypertensive patients with no other systemic disease. The patients were randomized to receive nebivolol 5 mg (30 patients; 21 women, 9 men; mean age 48.4 ± 11.4 years) and valsartan 160 mg (30 patients; 21 women, 9 men; mean age 49.8 ± 11.3 years). All the patients underwent tissue Doppler echocardiographic examination before and three months after treatment to compare the effects of the two drugs on atrial electromechanical coupling.
Baseline blood pressures, electrocardiographic and echocardiographic findings, and atrial electromechanical coupling were similar in both groups (p>0.05). Both drugs significantly reduced blood pressure after treatment, with similar efficacy (p>0.05). Atrial electromechanical coupling time intervals showed significant decreases in both groups.
Prolonged interatrial electromechanical time intervals in hypertensives are improved with antihypertensive treatment.
高血压是心房颤动（AF）发生的重要心血管危险因素。通过组织多普勒测量的心房机电耦合时间间隔增加被认为是预测高血压患者发生AF的重要因素。本研究的目的是比较血管紧张素受体阻滞剂缬沙坦和β受体阻滞剂奈必洛尔对新诊断的1期高血压患者心房机电耦合的影响。
该研究纳入了60例新诊断的1期高血压患者，无其他全身性疾病。患者被随机分为接受5mg奈必洛尔（30例患者；21名女性，9名男性；平均年龄48.4±11.4岁）和160mg缬沙坦（30例患者；21名女性，9名男性；平均年龄49.8±11.3岁）。所有患者在治疗前和治疗三个月后均接受组织多普勒超声心动图检查，以比较两种药物对心房机电耦合的影响。
两组患者的基线血压、心电图和超声心动图结果以及心房机电耦合情况相似（p>0.05）。两种药物治疗后均显著降低血压，疗效相似（p>0.05）。两组患者的心房机电耦合时间间隔均显著缩短。
高血压患者延长的心房机电时间间隔通过降压治疗得到改善。
