Department of Family Medicine, Agri Military Hospital, Agri, Turkey.
Med Hypotheses. 2012 Sep;79(3):294-8. doi: 10.1016/j.mehy.2012.05.011. Epub 2012 Jun 13.
Long pentraxin 3 (PTX3) is a recently discovered multimeric inflammatory mediator that is structurally linked to short pentraxins, such as C-reactive protein (CRP) and serum amyloid P component. PTX3 is produced by a variety of tissues and cells, including vascular endothelial cells and macrophages. Because of its extrahepatic synthesis (in contrast to CRP), the PTX3 level is believed to be a true independent indicator of disease activity because PTX3 is produced at sites of inflammation and is intimately linked to endothelial dysfunction. PTX3 also has key functions in innate immunity and has been identified in atherosclerotic lesions. Previously, PTX3 was associated with myocyte damage in myocardial infarction (MI), mortality after MI, and unstable angina. Because PTX3 release is likely a specific response to vascular damage, PTX3 levels may provide more explicit information on development and progression of atherosclerosis than nonspecific markers like CRP and interleukin-6. Asymmetric dimethylarginine (ADMA) is a naturally occurring component of human blood plasma. More than one decade ago ADMA was first reported to exert biological effects by inhibiting nitric oxide synthesis. Many researchers today agree that ADMA may play a prominent role in the pathogenesis and in the progression of cardiovascular diseases. In this study PTX3 and ADMA levels investigated of valsartan and nebivolol's effect on newly diagnosed hypertensive patients.
长型五聚素 3（PTX3）是一种最近发现的多聚体炎症介质，其结构与短五聚素（如 C 反应蛋白（CRP）和血清淀粉样蛋白 P 成分）相关联。PTX3 由多种组织和细胞产生，包括血管内皮细胞和巨噬细胞。由于其在肝外合成（与 CRP 相反），PTX3 水平被认为是疾病活动的真正独立指标，因为 PTX3 在炎症部位产生，与内皮功能障碍密切相关。PTX3 在先天免疫中也具有关键功能，并在动脉粥样硬化病变中被识别。此前，PTX3 与心肌梗死（MI）中的心肌细胞损伤、MI 后的死亡率和不稳定型心绞痛有关。由于 PTX3 的释放可能是对血管损伤的特定反应，因此 PTX3 水平可能比 CRP 和白细胞介素-6 等非特异性标志物提供关于动脉粥样硬化发展和进展的更明确信息。不对称二甲基精氨酸（ADMA）是人类血浆中的一种天然成分。十多年前，ADMA 首次被报道通过抑制一氧化氮合成来发挥生物学作用。今天，许多研究人员都认为 ADMA 可能在心血管疾病的发病机制和进展中发挥突出作用。在这项研究中，研究了缬沙坦和比索洛尔对新诊断的高血压患者的 PTX3 和 ADMA 水平的影响。
