School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Scotland. UK.
Rheumatology (Oxford). 2011 Dec;50(12):2251-6. doi: 10.1093/rheumatology/ker276. Epub 2011 Oct 8.
To determine whether a high BMI in childhood or early adulthood has a long-term influence on the likelihood of knee pain.
A birth cohort study of persons born during first week of 1958 in Great Britain. Participants were followed up throughout childhood and adulthood, most recently at 45 years, when information was collected on knee pain. Information on BMI was collected at follow-up intervals throughout childhood and adulthood. RESULTS; A total of 8579 individuals participated and the prevalence of being overweight and obesity increased throughout life from 0.2% at the age of 7 years to 65.5% at the age of 45 years. A total of 1636 individuals reported knee pain at the age of 45 years, giving a prevalence of 19.1% (95% CI 18.2, 19.9%). BMI was associated with knee pain: persons with a BMI of >30 kg/m(2) at 23, 33 or 45 years experienced approximately a doubling in the risk of knee pain at 45 years. There was a significant association with knee pain at the age of 45 years with high BMI from as early as age 11 years, but the association was stronger at the age of 16 years [relative risk (RR)(BMI 20-25) (v)(s) (<20) = 1.2 (95% CI 1.1, 1.3); RR(25-30) = 1.3 (95% CI 1.1, 1.6); RR(>30) = 1.6 (95% CI 1.05, 2.4)].
This study has demonstrated the long-term effects of childhood and early adult obesity and the importance of early intervention programmes to try to reduce weight and maintain weight loss.
确定儿童期或成年早期的高 BMI 是否对膝关节疼痛的可能性有长期影响。
这是一项针对英国 1958 年第一周期间出生人群的出生队列研究。参与者在整个儿童期和成年期接受随访，最近在 45 岁时收集膝关节疼痛信息。在整个儿童期和成年期的随访间隔中收集 BMI 信息。
共有 8579 人参与，超重和肥胖的患病率在整个生命过程中逐渐增加，从 7 岁时的 0.2%增加到 45 岁时的 65.5%。共有 1636 人在 45 岁时报告膝关节疼痛，患病率为 19.1%（95%CI 18.2，19.9%）。BMI 与膝关节疼痛相关：23、33 或 45 岁时 BMI 大于 30kg/m2 的人，在 45 岁时膝关节疼痛的风险增加约一倍。从 11 岁开始，就与膝关节疼痛有明显的关联，但是在 16 岁时关联更强[相对风险（RR）（BMI 20-25）（v）（s）（<20）=1.2（95%CI 1.1，1.3）；RR（25-30）=1.3（95%CI 1.1，1.6）；RR（>30）=1.6（95%CI 1.05，2.4）]。
本研究表明了儿童期和成年早期肥胖的长期影响，以及实施早期干预计划以尝试减轻体重和保持减肥效果的重要性。
