Li Bin, Chen Gang, Bai Jiao, Jing Yong-Kui, Pei Yue-Hu
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
J Asian Nat Prod Res. 2011 Dec;13(12):1146-50. doi: 10.1080/10286020.2011.617744. Epub 2011 Oct 10.
A new bisamide N₁-acetyl-N₇-phenylacetyl cadaverine (1) and a series of diketopiperazines including a new diketopiperazine cyclo(2-hydroxy-Pro-R-Leu) (2), together with a new natural product cyclo(4-hydroxy-S-Pro-S-Trp) (3) and two known leucine-based diketopiperazines cyclo(4-hydroxy-R-Pro-S-Leu) (4) and cyclo (S-Pro-R-Leu) (5), were isolated from ethyl acetate extract of a fermentation broth of a marine-derived Streptomyces sp. Their structures were elucidated by the interpretation of spectroscopic analysis. The antitumor activities of compounds 1-3 against HL-60 cell lines were tested by MTT assay.
从一株海洋来源的链霉菌属发酵液的乙酸乙酯提取物中分离出一种新的双酰胺N₁-乙酰基-N₇-苯乙酰基尸胺（1）、一系列二酮哌嗪，包括一种新的二酮哌嗪环（2-羟基-L-脯氨酸-L-亮氨酸）（2），以及一种新的天然产物环（4-羟基-L-脯氨酸-L-色氨酸）（3）和两种已知的基于亮氨酸的二酮哌嗪环（4-羟基-D-脯氨酸-L-亮氨酸）（4）和环（D-脯氨酸-L-亮氨酸）（5）。通过光谱分析的解释阐明了它们的结构。采用MTT法检测了化合物1-3对HL-60细胞系的抗肿瘤活性。
