Dellamonica P, Mondain V, Bernard E
Service des Maladies Infectieuses et Tropicales, Hôpital de l'Archet, Nice, France.
Pathol Biol (Paris). 1990 Apr;38(4):298-301.
For the HIV positive patient, salmonella raises numerous epidemiological and therapeutic problems. This microorganism, quite common before zidovudine therapy, seems to have diminished since this antiviral also has an antibiotic activity against salmonella. When bacterial contamination occurs, the decreased immunitary activity might play a role, but hypochloridria, frequently afflicting these patients, might also be involved. Therapeutically, antibiotics with high intramacrophagic diffusion yield excellent results and limit the incidence of recurrence. The effect of gamma interferon is well documented in vitro. However, the efficacy of these quinolones does not lead us to believe that it is the treatment of choice.
对于艾滋病毒呈阳性的患者来说，沙门氏菌引发了诸多流行病学和治疗方面的问题。这种微生物在齐多夫定治疗之前相当常见，自从这种抗病毒药物也对沙门氏菌具有抗生素活性以来，它似乎已经减少。当发生细菌污染时，免疫活性降低可能起作用，但这些患者经常出现的胃酸过少也可能与之有关。在治疗方面，巨噬细胞内扩散率高的抗生素能产生极佳效果，并限制复发率。γ干扰素的作用在体外有充分记录。然而，这些喹诺酮类药物的疗效并未让我们相信它是首选治疗方法。
