School of Pharmacy, Lanzhou University, Lanzhou, Gansu Province 730000, China.
Nat Prod Res. 2012;26(11):1038-44. doi: 10.1080/14786419.2010.551643. Epub 2011 Oct 10.
The anti-inflammatory activity and the mechanism of action of Gentiana striata Maxim. has been investigated. The most active phase, the ethyl acetate extract of Gentiana striata Maxim. (EGS), displayed potent inhibitory activity on feet oedema of rheumatoid arthritis (RA) inflicted rats. This anti-inflammatory activity might be partly based on the notable reduction of prostaglandin E2 (PGE₂) and nitric oxide (NO) levels. Six further compounds isolated from EGS have previously been reported as having anti-inflammatory activity.
对秦艽的抗炎活性及其作用机制进行了研究。最活跃的相，秦艽的乙酸乙酯提取物（EGS），对类风湿性关节炎（RA）致大鼠足肿胀显示出强大的抑制活性。这种抗炎活性可能部分基于前列腺素 E2（PGE₂）和一氧化氮（NO）水平的显著降低。从 EGS 中分离得到的另外 6 种化合物以前曾被报道具有抗炎活性。
