秦艽（龙胆科）提取物对大鼠类风湿性关节炎的抑制作用。

Inhibitory effects of the Gentiana macrophylla (Gentianaceae) extract on rheumatoid arthritis of rats.

作者信息

Yu Farong, Yu Fahong, Li Rende, Wang Rui

机构信息

Gansu Institute of Political Science and Law, Lanzhou 730070, China.

出版信息

J Ethnopharmacol. 2004 Nov;95(1):77-81. doi: 10.1016/j.jep.2004.06.025.

DOI:10.1016/j.jep.2004.06.025

PMID:15374610

Abstract

Acute treatment of rheumatoid rats with an extract from the roots of Gentiana macrophylla (Gentianaceae) produced a significant inhibitory effect on rheumatoid arthritis (RA). When rats were administered the Gentiana macrophylla extract orally at a daily dose of 100 mg/kg body weight, the prostaglandin E(2) (PGE(2)) levels in the inflammatory tissues, sole thickness, and ankle circumferences of feet were significantly decreased. The anti-inflammatory activity observed in Gentiana macrophylla is comparable to that observed in prednisone. These observations suggest that Gentiana macrophylla displays considerable potency in anti-inflammatory action and could be used as an anti-inflammatory agent in the control of inflammation of rheumatoid arthritis.

摘要

用秦艽（龙胆科）根提取物对类风湿性大鼠进行急性治疗，对类风湿性关节炎（RA）产生了显著的抑制作用。当以每日100 mg/kg体重的剂量给大鼠口服秦艽提取物时，炎症组织中的前列腺素E2（PGE2）水平、脚掌厚度和脚踝周长均显著降低。秦艽中观察到的抗炎活性与泼尼松中观察到的相当。这些观察结果表明，秦艽在抗炎作用方面具有相当大的效力，可作为控制类风湿性关节炎炎症的抗炎剂。