Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Groningen, the Netherlands.
BJOG. 2011 Dec;118(13):1658-60. doi: 10.1111/j.1471-0528.2011.03138.x. Epub 2011 Oct 10.
We questioned if participation in the HYPITAT trial (induction of labour versus expectant monitoring in women with gestational hypertension or pre-eclampsia at term) impacted implementation of its results and subsequently maternal health. We identified women with hypertensive disease from the Perinatal Registry, and distinguished the period before, during and after the trial. We included 43 641 women. Induction of labour increased from 58.3 to 67.1% (P < 0.001) and prevalence of eclampsia decreased from 0.85 to 0.19% (P < 0.001) before and after the trial. Concurrently, participation in the HYPITAT trial among others had immediate consequences for obstetric management and maternal health.
我们质疑参与 HYPITAT 试验（在足月时患有妊娠高血压或子痫前期的妇女中进行引产与期待监测）是否会影响其结果的实施，进而影响产妇健康。我们从围产期登记处确定了患有高血压疾病的妇女，并区分了试验前后的时期。我们纳入了 43641 名妇女。试验前后，引产率从 58.3%增加到 67.1%（P<0.001），子痫发生率从 0.85%降至 0.19%（P<0.001）。同时，参与 HYPITAT 试验等因素对产科管理和产妇健康产生了直接影响。
