Service of Endocrinology, University Hospital Dr Peset, Valencia, Spain.
Eur J Clin Invest. 2012 May;42(5):503-9. doi: 10.1111/j.1365-2362.2011.02606.x. Epub 2011 Oct 10.
Circulating C3 levels are elevated in obese patients, but how this factor is affected after weight loss through diet is a question that is yet unanswered. Therefore, the aim of this study was to evaluate the effects of weight loss on lipid and hydrocarbonated metabolism parameters and on the levels of C3 and C4 components of complement in obese patients.
This is a longitudinal intervention study based on a 6-week very low-calorie diet (VLCD), a liquid formula of 603 kcal/day. A total of 131 middle-aged patients were distributed among grades II, III and IV of obesity. Anthropometric parameters, total cholesterol, triglycerides, high-density lipoprotein cholesterol, LDLc, apolipoproteins A-I and B-100, glucose, insulin, HOMA-IR and C3 and C4 levels were evaluated at baseline and after 6 weeks of intervention.
After VLCD, the moderate weight loss was accompanied by a significant reduction in C3 levels in grade III and grade IV patients (10.2% and 15.4%, respectively; P < 0.001). C4 levels were not altered. Adherence to the diet improved anthropometric parameters and was accompanied by a significant decrease in all lipid profile parameters (P < 0.001). In addition, weight loss was associated with an improvement in hydrocarbonated metabolism as shown by the decrease in glucose levels and HOMA-IR (P < 0.01).
Our findings show that in severely obese patients following a VLCD for 6 weeks produces reductions in factor C3, a biomarker of cardiovascular disease, and a significant improvement in some features of metabolic syndrome. In this way, the abovementioned diet may represent an effective strategy for treating obesity and related cardiovascular risk factors.
肥胖患者的循环 C3 水平升高，但通过饮食减肥后这种因素如何受到影响仍未得到解答。因此，本研究旨在评估减肥对脂质和碳水化合物代谢参数以及补体 C3 和 C4 成分水平的影响在肥胖患者中。
这是一项基于为期 6 周极低热量饮食（VLCD）的纵向干预研究，每天摄入 603 卡路里的液体配方。共有 131 名中年患者分布在肥胖 II 级、III 级和 IV 级。在基线和干预 6 周后评估了体重指数、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、LDLc、载脂蛋白 A-I 和 B-100、葡萄糖、胰岛素、HOMA-IR 以及 C3 和 C4 水平。
在 VLCD 后，中度减重伴随着 III 级和 IV 级患者 C3 水平显著降低（分别为 10.2%和 15.4%；P<0.001）。C4 水平没有改变。饮食依从性改善了体重指数参数，并伴有所有血脂参数显著降低（P<0.001）。此外，体重减轻与碳水化合物代谢的改善相关，表现为葡萄糖水平和 HOMA-IR 的降低（P<0.01）。
我们的发现表明，在严重肥胖患者中，6 周的 VLCD 可降低心血管疾病的生物标志物 C3，并显著改善代谢综合征的某些特征。通过这种方式，上述饮食可能代表治疗肥胖和相关心血管危险因素的有效策略。
