Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia 741222, West Bengal, India.
Nat Prod Res. 2012;26(17):1631-3. doi: 10.1080/14786419.2011.585463. Epub 2011 Oct 10.
Diospyros cordifolia Roxb. (Ebenaceae), commonly known as Indian ebony, is used traditionally for several medicinal purposes. In this study, the methanol extract of D. cordifolia bark (MEDC) was evaluated for its antitumour effect against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumour (EAC) cells in mice, MEDC was administered intraperitoneally at 25 and 50 mg kg⁻¹ bodyweight for 9 consecutive days. On the 10th day, half of the mice were sacrificed to determine the tumour volume, viable and non-viable tumour cell counts, and rest were kept alive for the assessment of median survival time and increase in life span. Haematological profiles were also determined. MEDC exhibited a marked decrease in tumour growth parameters and increased the survival rate of EAC-bearing animals. MEDC normalised the haematological parameters as compared with the EAC control mice. Therefore, this study demonstrated that D. cordifolia bark possessed remarkable antitumour efficacy.
柿树（柿树科），俗称印度乌木，传统上用于多种药用目的。在这项研究中，评估了柿树树皮甲醇提取物（MEDC）对荷 Ehrlich 腹水癌（EAC）瑞士白化病小鼠的抗肿瘤作用。在小鼠腹腔接种肿瘤（EAC）细胞 24 小时后，连续 9 天每天腹腔内给予 MEDC25 和 50mgkg-1体重。第 10 天，一半的小鼠被处死以确定肿瘤体积、活和死肿瘤细胞计数，其余的则存活下来以评估中位生存时间和延长寿命。还确定了血液学参数。MEDC 显著降低了肿瘤生长参数并提高了荷 EAC 动物的存活率。与 EAC 对照组相比，MEDC 使血液学参数正常化。因此，这项研究表明柿树树皮具有显著的抗肿瘤功效。
