Bengal Institute of Pharmaceutical Sciences, Kalyani , Nadia 741235, India.
Nat Prod Res. 2012;26(12):1141-4. doi: 10.1080/14786419.2011.561206. Epub 2011 Oct 24.
Terminalia arjuna Roxb. (Combretaceae), commonly known as 'Arjuna', is a large tree occurring throughout the Indian peninsula. This study was undertaken to evaluate the methanol extract of T. arjuna leaf (META) for antitumour activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty-four hours after intraperitonial inoculation of tumour (EAC) cells in mice, META was administered at 100 and 200 mg kg(-1) body weights for 9 consecutive days. On day 10, half of the mice were sacrificed and the rest kept alive for an assessment of the increase in life span. The antitumour effect of META was assessed by evaluating tumour volume, tumour weight, viable and non-viable tumour cell counts, median survival time and increase in life span of EAC-bearing hosts. Haematological profiles were estimated. META showed a significant (p<0.001) decrease in tumour volume, tumour weight and viable cell count, and also increased the life span of EAC-bearing mice. Haematological profiles were significantly (p<0.001) restored to normal levels in META-treated mice compared to the EAC control. Therefore, from this study, it can be concluded that T. arjuna leaf exhibited remarkable antitumour activity against EAC in Swiss mice.
Terminalia arjuna Roxb.（使君子科），俗称“Arjuna”，是一种广泛分布于印度半岛的大树。本研究旨在评估 Terminalia arjuna 叶的甲醇提取物（META）对瑞士白化病小鼠的 Ehrlich 腹水癌（EAC）的抗肿瘤活性。在小鼠腹腔内接种肿瘤（EAC）细胞 24 小时后，给予 META 100 和 200mg/kg 体重，连续 9 天。第 10 天，一半的小鼠被处死，其余的继续存活以评估寿命的延长。通过评估肿瘤体积、肿瘤重量、存活和非存活肿瘤细胞计数、中位生存时间和 EAC 荷瘤宿主的寿命延长来评估 META 的抗肿瘤作用。估计了血液学特征。META 显著（p<0.001）降低了肿瘤体积、肿瘤重量和存活细胞计数，并延长了 EAC 荷瘤小鼠的寿命。与 EAC 对照组相比，META 治疗的小鼠的血液学特征明显（p<0.001）恢复到正常水平。因此，从这项研究可以得出结论，Terminalia arjuna 叶对瑞士小鼠的 EAC 表现出显著的抗肿瘤活性。
