Institute of Community Medicine, University of Greifswald, Greifswald, Germany.
Ann Nutr Metab. 2011 Oct;58(4):335-42. doi: 10.1159/000331991. Epub 2011 Oct 7.
It has not been investigated whether there are associations between urinary iodine (UI) excretion measurements some years apart, nor whether such an association remains after adjustment for nutritional habits. The aim of the present study was to investigate the relation between iodine-creatinine ratio (ICR) at two measuring points 5 years apart.
Data from 2,659 individuals from the Study of Health in Pomerania were analyzed. Analysis of covariance and Poisson regressions were used to associate baseline with follow-up ICR.
Baseline ICR was associated with follow-up ICR. Particularly, baseline ICR >300 μg/g was related to an ICR >300 μg/g at follow-up (relative risk, RR: 2.20; p < 0.001). The association was stronger in males (RR: 2.64; p < 0.001) than in females (RR: 1.64; p = 0.007). In contrast, baseline ICR <100 μg/g was only associated with an ICR <100 μg/g at follow-up in males when considering unadjusted ICR.
We detected only a weak correlation with respect to low ICR. Studies assessing iodine status in a population should take into account that an individual with a low UI excretion in one measurement is not necessarily permanently iodine deficient. On the other hand, current high ICR could have been predicted by high ICR 5 years ago.
目前尚未研究相隔数年的尿碘（UI）排泄测量值之间是否存在关联，也未研究在调整营养习惯后，这种关联是否仍然存在。本研究旨在调查相隔 5 年的两次碘肌酐比（ICR）测量值之间的关系。
分析了来自波美拉尼亚健康研究的 2659 名个体的数据。使用协方差分析和泊松回归来关联基线和随访 ICR。
基线 ICR 与随访 ICR 相关。特别是，基线 ICR >300μg/g 与随访时的 ICR >300μg/g 相关（相对风险，RR：2.20；p<0.001）。这种关联在男性中更强（RR：2.64；p<0.001），而在女性中较弱（RR：1.64；p=0.007）。相比之下，在未调整的 ICR 中，仅在男性中，基线 ICR <100μg/g 仅与随访时的 ICR <100μg/g 相关。
我们仅检测到低 ICR 值之间的弱相关性。评估人群中碘状况的研究应考虑到，在一次测量中尿碘排泄量低的个体不一定会持续缺乏碘。另一方面，目前的高 ICR 可能是由 5 年前的高 ICR 预测的。
