Mafauzy M, Mohamad W B, Anum M Y, Musalmah M
Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Southeast Asian J Trop Med Public Health. 1995 Mar;26(1):138-42.
A total of 2,034 subjects aged 15 years and above from different parts of the State of Kelantan were studied to determine goiter size and urinary iodine excretion. The State was divided into 2 areas - area 1 consisting of localities in the districts near the coast and area 2 consisting of localities in the inland districts. There were 1,050 subjects in area 1 and 984 subjects in areas 2. The mean age (+/- SE) of subjects in areas 1 and 2 were 38.2 + 0.5 and 37.1 +/- 0.5 years, respectively. The prevalence of goiter was 31.4% in area 1 and 45.0% in area 2; the difference was statistically significant (p < 0.05). However, the prevalence of large and visible goiters (grades II and III) was only 2.0% in area 1 and 3.3% in area 2; the difference was not statistically significant. The mean (+/- SD) urinary iodine excretion in areas 1 and 2 was 57.1 +/- 2.1 and 56.8 +/- 2.1 micrograms I/g Cr, respectively. The values were below those recommended by WHO. There was no significant difference in urinary iodine excretion between those with and without goiters in both areas and also between the grades of goiters. There were significantly more females with goiters than males in both areas but there was no significant difference in the urinary iodine excretion between the 2 sexes. Thus based on urinary iodine excretion, the iodine intake of the population in this area, was suboptimal and this was associated with a high prevalence of goiter.
对来自吉兰丹州不同地区的2034名15岁及以上的受试者进行了研究，以确定甲状腺肿大小和尿碘排泄情况。该州分为两个区域——区域1包括沿海地区附近各区的地点，区域2包括内陆地区各区的地点。区域1有1050名受试者，区域2有984名受试者。区域1和区域2受试者的平均年龄（±标准误）分别为38.2±0.5岁和37.1±0.5岁。区域1甲状腺肿患病率为31.4%，区域2为45.0%；差异具有统计学意义（p<0.05）。然而，大的且可见的甲状腺肿（II级和III级）患病率在区域1仅为2.0%，在区域2为3.3%；差异无统计学意义。区域1和区域2的平均（±标准差）尿碘排泄分别为57.1±2.1和56.8±2.1微克碘/克肌酐。这些值低于世界卫生组织推荐的值。两个区域有甲状腺肿者和无甲状腺肿者之间以及不同等级甲状腺肿者之间的尿碘排泄均无显著差异。两个区域甲状腺肿女性均显著多于男性，但两性之间的尿碘排泄无显著差异。因此，基于尿碘排泄情况，该地区人群的碘摄入量未达最佳水平，且这与甲状腺肿的高患病率相关。
