Yao X, Zhou L, Han S, Chen Y
Department of Hepatobiliary Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, China.
J Int Med Res. 2011;39(4):1253-64. doi: 10.1177/147323001103900413.
Chemokine receptors play a prominent role in cancer progression and metastasis. This study investigated whether the expression of CXC chemokine receptor types 4 and 7 (CXCR4 and CXCR7, respectively), determined immunohistochemically, was associated with clinicopathological characteristics and postoperative survival in gallbladder cancer specimens from 72 patients. CXCR4 was detected in the cytoplasm and/or nucleus of gallbladder cancer cells, but CXCR7 was detected only in the cytoplasm. Expression of either CXCR7 or CXCR4 in the cytoplasm was associated with tumour stage. Expression of nuclear CXCR4 was associated with lymph node metastases and lymphatic invasion. Cytoplasmic expression of CXCR4 and CXCR7 were each independent risk factors for worse postoperative survival. Further research is required to clarify the mechanisms involved in these associations and to determine their potential prognostic and therapeutic implications.
趋化因子受体在癌症进展和转移中起着重要作用。本研究调查了通过免疫组织化学测定的CXC趋化因子受体4型和7型（分别为CXCR4和CXCR7）的表达是否与72例胆囊癌患者标本的临床病理特征及术后生存率相关。CXCR4在胆囊癌细胞的细胞质和/或细胞核中被检测到，但CXCR7仅在细胞质中被检测到。CXCR7或CXCR4在细胞质中的表达与肿瘤分期相关。细胞核CXCR4的表达与淋巴结转移和淋巴管浸润相关。CXCR4和CXCR7在细胞质中的表达均是术后生存率较差的独立危险因素。需要进一步研究以阐明这些关联所涉及的机制，并确定它们潜在的预后和治疗意义。
