Feng L-Z, Zheng X-Y, Zhou L-X, Fu B, Yu Y-W, Lu S-C, Cao N-S
Department of Surgery, The Second Hospital of Jiaxing City, Jiaxing, Zhejiang Province, China.
J Int Med Res. 2011;39(4):1333-43. doi: 10.1177/147323001103900420.
This semiquantitative immunohistochemical study investigated the clinical significance of S100A4 and vascular endothelial growth factor C (VEGF-C) protein expression in gastric carcinoma. Correlations between S100A4 and VEGF-C immunoreactivity and clinicopathological characteristics were evaluated using 108 gastric carcinoma specimens and 20 specimens of tissue adjacent to gastric carcinoma. S100A4 and VEGF-C expression in carcinoma was higher than that in adjacent tissues. S100A4 expression was significantly related to tumour size and lymph node metastasis, whereas VEGF-C expression was associated with invasion depth, lymph node metastasis and tumour, node, metastasis (TNM) stage. A significant correlation was found between S100A4 and VEGF-C expression. Patients expressing S100A4 or VEGF-C showed no significant reduction in 5-year survival rate compared with those not expressing these proteins. Sex, age, tumour size, invasion depth, lymph node involvement, TNM stage, S100A4 expression and VEGF-C expression had a common effect on carcinoma prognosis but none was an independent prognostic factor.
这项半定量免疫组织化学研究探讨了S100A4和血管内皮生长因子C（VEGF-C）蛋白表达在胃癌中的临床意义。使用108例胃癌标本和20例胃癌旁组织标本评估S100A4和VEGF-C免疫反应性与临床病理特征之间的相关性。癌组织中S100A4和VEGF-C的表达高于邻近组织。S100A4表达与肿瘤大小和淋巴结转移显著相关，而VEGF-C表达与浸润深度、淋巴结转移和肿瘤-淋巴结-转移（TNM）分期有关。发现S100A4和VEGF-C表达之间存在显著相关性。与不表达这些蛋白的患者相比，表达S100A4或VEGF-C的患者5年生存率没有显著降低。性别、年龄、肿瘤大小、浸润深度、淋巴结受累情况、TNM分期、S100A4表达和VEGF-C表达对癌预后有共同影响，但均不是独立的预后因素。
