Department of Radiation Oncology, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan, ROC.
Neuroepidemiology. 2011;37(2):114-9. doi: 10.1159/000331489. Epub 2011 Oct 7.
Patients with Parkinson's disease (PD) are suggested to be at a lower risk for the development of certain cancers and at a higher risk for melanoma. The aim of this study is to evaluate the possible association between PD and malignancy in Taiwan.
We used the data of the National Health Insurance System of Taiwan to assess this issue. The PD cohort contained 4,957 patients, and each patient was randomly frequency matched by age and sex with 4 people from the general population without PD. Cox's proportional hazard regression analysis was conducted to estimate the effects of PD on the cancer risk.
In patients with PD, the risk of developing overall cancer was marginally significantly lower than in subjects without PD [adjusted hazard ratio (HR) = 0.88; 95% CI = 0.78-0.99]. For individual cancers, the risks of developing colorectal and lung cancers among patients with PD were marginally significantly lower than in subjects without PD. In contrast, despite the higher HR for the development of melanoma, it did not reach statistical significance because of the relatively small sample size.
Our study found that Taiwanese patients with PD have a lower risk of developing colorectal and lung cancers. The findings of this study are compatible with those of prior studies from other countries.
帕金森病（PD）患者发生某些癌症的风险较低，而黑色素瘤的风险较高。本研究旨在评估台湾 PD 与恶性肿瘤之间的可能关联。
我们使用了台湾全民健康保险系统的数据来评估这个问题。PD 队列包含 4957 名患者，每位患者按年龄和性别与没有 PD 的普通人群中的 4 人进行随机频数匹配。采用 Cox 比例风险回归分析来估计 PD 对癌症风险的影响。
PD 患者发生总体癌症的风险明显低于无 PD 患者[校正后的危险比（HR）=0.88；95%可信区间（CI）=0.78-0.99]。对于个别癌症，PD 患者发生结直肠癌和肺癌的风险明显低于无 PD 患者。相比之下，尽管黑色素瘤的发生风险 HR 较高，但由于样本量较小，未达到统计学意义。
本研究发现台湾 PD 患者发生结直肠癌和肺癌的风险较低。这些发现与其他国家的先前研究结果一致。
