From the Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Management Office for Health Data; China Medical University Hospital, Department of Oral and Maxillofacial Surgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Department of Nuclear Medicine and PET Center, China Medical University Hospital and Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
From the Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Management Office for Health Data; China Medical University Hospital, Department of Oral and Maxillofacial Surgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Department of Nuclear Medicine and PET Center, China Medical University Hospital and Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan From the Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Management Office for Health Data; China Medical University Hospital, Department of Oral and Maxillofacial Surgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Department of Nuclear Medicine and PET Center, China Medical University Hospital and Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
QJM. 2014 Oct;107(10):805-12. doi: 10.1093/qjmed/hcu078. Epub 2014 Apr 10.
The aim of our study was to evaluate the relationship between routine treatment of periodontal disease (PD) and the subsequent risks for cancers in Taiwan.
Study participants were selected from the Taiwan National Health Insurance (NHI) system database. The PD with a routine treatment cohort contained 38 902 patients. For each treatment cohort participant, two age- and sex-matched comparison (control) cohort participants were randomly selected. Cox's proportional hazards regression analysis was used to estimate the effects of PD with treatment on the subsequent risk of cancer.
The overall risk of developing cancer was significantly lower in the treatment cohort than in the patients without treatment (adjusted Hazard ratio = 0.72, 95% confidence interval = 0.68-0.76). The risks of developing most gastrointestinal tract, lung, gynecological and brain malignancies were significantly lower in the treatment cohort than in the comparison cohort. In contrast, the risks of prostate and thyroid cancers were significantly higher in the treatment cohort than in the comparison cohort.
Our findings suggest that PD with treatment is associated with a significantly reduced overall risk of cancer and reduced risks of certain types of cancers.
本研究旨在评估台湾地区牙周病（PD）常规治疗与随后癌症风险之间的关系。
研究对象选自台湾全民健康保险（NHI）系统数据库。PD 常规治疗队列包含 38902 名患者。为每个治疗队列的参与者，随机选择两名年龄和性别匹配的对照（对照）队列参与者。采用 Cox 比例风险回归分析评估 PD 治疗对癌症后续风险的影响。
与未治疗患者相比，治疗组总体癌症发病风险显著降低（调整后的危险比=0.72，95%置信区间=0.68-0.76）。治疗组发生大多数胃肠道、肺部、妇科和脑恶性肿瘤的风险明显低于对照组。相比之下，治疗组前列腺癌和甲状腺癌的发病风险明显高于对照组。
我们的研究结果表明，PD 治疗与癌症总风险显著降低以及某些类型癌症风险降低相关。
