Casas E, Serrano C, Daimiel E, Michán A, Mateos F, García Puig J
Servicios de Medicina Interna, Hospital, La Paz, Madrid.
Rev Clin Esp. 1990 Mar;186(5):211-5.
A prospective analysis of 27,987 serum samples revealed a uricemia less than 2.0 mg/dl in 172 patients (prevalence of 0.61%). One hundred and six patients were being treated with more than one drug. Amongst the 21 hypouricemic patients receiving only one drug the more frequently associated drugs were beta-lactamases, salicylates at high doses, and carbamazepine. Out of the 45 hypouricemic patients who were under no treatment, there were 12 cases of pregnancies, 6 had a neoplastic disease, 2 suffered chronic hepatopathy and one presented hereditary xanthinuria. Out of 7 non treated patients, 6 were uric acid hypersecretors and only one was hyposecretor. The results indicate that hypouricemia: a) is usually associated with an elevated renal excretion of uric acid and b) it is frequently associated with the administration of drugs although it can also be included in the context of multiple systemic disease.
对27987份血清样本的前瞻性分析显示，172例患者存在血尿酸水平低于2.0mg/dl的情况（患病率为0.61%）。106例患者正在接受不止一种药物治疗。在仅接受一种药物治疗的21例低尿酸血症患者中，最常涉及的药物是β-内酰胺酶、高剂量水杨酸盐和卡马西平。在45例未接受治疗的低尿酸血症患者中，有12例处于妊娠期，6例患有肿瘤疾病，2例患有慢性肝病，1例患有遗传性黄嘌呤尿症。在7例未接受治疗的患者中，6例为尿酸高分泌者，仅1例为低分泌者。结果表明，低尿酸血症：a）通常与尿酸肾排泄增加有关；b）虽然它也可能与多种全身性疾病有关，但它经常与药物的使用有关。
