De Marzio P, Morelli S, Guido V, Aguglia F, Balsano F
Istituto di I Clinica medica, Fondazione Andrea Cesalpino, Università La Sapienza, Roma.
Recenti Prog Med. 1990 Apr;81(4):228-34.
The current techniques of respiratory gas-exchange monitoring during stress testing in patients with congestive heart failure have provided new physiopathologic and clinical data. The "breath-by-breath" measurement of oxygen consumption and carbon dioxide production and the evaluation of the relationship between these parameters and respiratory volumes, allow to determine both ventilatory and metabolic responses during exercise, thus giving a precise estimate of the effective cardiopulmonary functional capacity. The demonstration of peripheral vascular and metabolic abnormalities by these techniques have provided new insights into the mechanism of dyspnea and fatigue in patients with heart failure. Although the relationship between respiratory and metabolic parameters and hemodynamics has been extensively studied, its mechanisms are still unclear. Moreover, controversy still exists as to the link between functional capacity and prognosis. Finally, recent studies on the cardiopulmonary adaptations to exercise training in patients with left ventricular dysfunction, have clearly demonstrated clinical and hemodynamic improvement after conditioning. These data, if confirmed, may provide a new approach in the management of patients with this disorder.
目前,在充血性心力衰竭患者进行压力测试期间监测呼吸气体交换的技术已经提供了新的生理病理和临床数据。对氧气消耗和二氧化碳产生进行“逐次呼吸”测量,并评估这些参数与呼吸量之间的关系,有助于确定运动期间的通气和代谢反应,从而精确估计有效的心肺功能能力。通过这些技术证明的外周血管和代谢异常,为深入了解心力衰竭患者呼吸困难和疲劳的机制提供了新的线索。尽管呼吸和代谢参数与血流动力学之间的关系已得到广泛研究,但其机制仍不清楚。此外,关于功能能力与预后之间的联系仍存在争议。最后,最近关于左心室功能障碍患者对运动训练的心肺适应性研究清楚地表明,在进行运动训练后,患者的临床症状和血流动力学得到了改善。这些数据如果得到证实,可能为这种疾病的患者管理提供一种新方法。