触珠蛋白多态性与黑人前列腺癌无关。

Haptoglobin polymorphism is not associated with prostate cancer in blacks.

机构信息

Department of Medical Laboratory Technology, Institute of Health Sciences, Gaborone, Botswana.

出版信息

Clin Chim Acta. 2012 Jan 18;413(1-2):334-6. doi: 10.1016/j.cca.2011.09.032. Epub 2011 Oct 2.

DOI:10.1016/j.cca.2011.09.032

PMID:21986563

Abstract

BACKGROUND

Prostate cancer (Pca) disease burden is highest among male blacks. Oxidative stress due to hemoglobin-related oxygen reactive species is a risk factor for cancer development. The polymorphic haptoglobin (Hp) protein inhibits hemoglobin-related oxidative stress. The antioxidant capacity of Hp is genetically determined. We studied the effect of Hp polymorphism on susceptibility to Pca.

SUBJECTS AND METHODS

In a case-control study, 201 participants (60 hospital-based controls, 62 benign prostate hypertrophy (BPH) and 79 prostate cancer (Pca) patients were studied. Serum prostate specific antigen (PSA) was measured using an immunoradiometric assay and Hp phenotype was determined using starch gel electrophoresis. Haptoglobin phenotype distribution was compared between groups according to disease state.

RESULTS

Serum PSA concentrations were markedly elevated in BPH and Pca patients compared to control subjects. Overall, Hp 1-1 was present in 50 individuals (25%), Hp 2-1 in 91 persons (46%) and 46 subjects (23%) had Hp 2-2. Thirteen individuals (6%) were anhaptoglobinaemic. The Hp1 allele frequency was not significantly different according to clinical history; 0.472 (95% CI 0.343-0.601), 0.567 (95% CI 0.395-0.619) and 0.507 (95% CI 0.441-0.693) for control group, BPH and Pca patients, respectively.

CONCLUSION

Our results suggest that Hp polymorphism is neither associated with risk of developing Pca nor outcome of the disease.

摘要

背景

前列腺癌（Pca）疾病负担在男性黑种人中最高。由于血红蛋白相关的氧活性物质引起的氧化应激是癌症发展的一个风险因素。多态性触珠蛋白（Hp）蛋白抑制血红蛋白相关的氧化应激。Hp 的抗氧化能力是由遗传决定的。我们研究了 Hp 多态性对前列腺癌易感性的影响。

受试者和方法

在一项病例对照研究中，研究了 201 名参与者（60 名基于医院的对照组、62 名良性前列腺增生（BPH）患者和 79 名前列腺癌（Pca）患者）。使用免疫放射测定法测量血清前列腺特异性抗原（PSA），并使用淀粉凝胶电泳法确定 Hp 表型。根据疾病状态比较各组之间的 Hp 表型分布。

结果

与对照组相比，BPH 和 Pca 患者的血清 PSA 浓度明显升高。总的来说，50 名个体（25%）存在 Hp 1-1，91 名个体（46%）存在 Hp 2-1，46 名个体（23%）存在 Hp 2-2。13 名个体（6%）为无触珠蛋白血症。Hp1 等位基因频率与临床病史无显著差异；对照组、BPH 和 Pca 患者分别为 0.472（95%CI 0.343-0.601）、0.567（95%CI 0.395-0.619）和 0.507（95%CI 0.441-0.693）。