妊娠相关血浆蛋白 A 多态性与子痫前期的关联：一项初步研究。
Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - a pilot study.
机构信息
Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U nemocnice 2, 128 08 Prague, Czech Republic.
出版信息
Clin Biochem. 2011 Dec;44(17-18):1380-4. doi: 10.1016/j.clinbiochem.2011.09.015. Epub 2011 Oct 2.
OBJECTIVES
The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies.
DESIGN AND METHODS
Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied together in 165 women in third trimester pregnancies complicated with threatening preterm labor (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls.
RESULTS
Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p=0.007).
CONCLUSION
Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results.
目的
本研究旨在探讨高危妊娠患者 PAPP-A（妊娠相关血浆蛋白 A）的遗传和生化背景。
设计和方法
在 165 名妊娠晚期有早产先兆（n=98）、子痫前期（n=35）、宫内生长受限（n=34）和 ICP（妊娠肝内胆汁淤积症）（n=15）的孕妇中，研究了 5 种 PAPP-A 基因多态性和 PAPP-A 母血清水平。114 名健康孕妇作为对照。
结果
与对照组相比，子痫前期患者 Cys327Cys 多态性的 TT 基因型频率显著升高（p<0.01）。ICP 患者的 PAPP-A 血清水平较对照组升高，与宫内生长受限患者的 CRP（C 反应蛋白）呈显著相关（r=0.49，p=0.007）。
结论
本研究表明，PAPP-A 基因 Cys327Cys 多态性的 TT 基因型与子痫前期有关。然而，需要进一步扩大子痫前期患者的研究来证实我们的结果。
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