Department of Anaesthesiology and Reanimation, Baskent University, Ankara, Turkey.
Eur J Anaesthesiol. 2011 Dec;28(12):836-41. doi: 10.1097/EJA.0b013e32834c580b.
Strabismus surgery is one of the most common ophthalmic surgical procedures in children and is associated with significant postoperative nausea and vomiting (PONV).
We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.
Prospective, placebo-controlled, randomised double-blind study.
University hospital.
Ninety children, between 2 and 14 years scheduled for strabismus surgery, were recruited. Eighty-six completed the study.
After induction of anaesthesia, intravenous dexamethasone 0.1 mg kg was administered to all. The patients were enrolled to receive either intravenous physiological saline (group S) or paracetamol 15 mg kg (group P).
Incidence of PONV in the first 24 h postoperatively.
General and clinical characteristics of the children were similar in both groups. PONV during the first 24 h was significantly higher in group S in comparison with group P (group S vs. group P, 33 vs. 14.6%, respectively, P = 0.038 for nausea; 24.4 vs. 7.3%, respectively, P = 0.030 for vomiting). The number of analgesic administrations during the first 24 h was higher in group S compared with group P (1.31 ± 0.85 and 0.73 ± 0.6, respectively, P = 0.001). The repeat number of postoperative analgesic administrations was significantly different between groups during the first 24 h (P = 0.005), but during 24-48 h was not significant.
Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.
斜视手术是儿童最常见的眼科手术之一，与术后恶心和呕吐（PONV）有显著关联。
我们评估了斜视手术后静脉注射扑热息痛对儿童 PONV 的影响。
前瞻性、安慰剂对照、随机双盲研究。
大学医院。
90 名 2 至 14 岁计划接受斜视手术的儿童被纳入研究。86 名患者完成了研究。
麻醉诱导后，所有患者均接受静脉注射地塞米松 0.1mg/kg。患者被随机分为两组，分别接受静脉注射生理盐水（S 组）或扑热息痛 15mg/kg（P 组）。
术后 24 小时内 PONV 的发生率。
两组儿童的一般和临床特征相似。与 P 组相比，S 组在术后 24 小时内 PONV 发生率明显更高（S 组 vs. P 组，分别为 33% vs. 14.6%，恶心，P=0.038；24.4% vs. 7.3%，呕吐，P=0.030）。S 组在术后 24 小时内需要的镇痛药物剂量也高于 P 组（1.31±0.85 和 0.73±0.6，P=0.001）。S 组和 P 组在术后 24 小时内需要重复使用术后镇痛药物的次数存在显著差异（P=0.005），但在 24-48 小时内无显著差异。
斜视手术后，术中静脉注射扑热息痛可降低儿童术后 24 小时内 PONV 的发生率。
