The effect of paracetamol on postoperative nausea and vomiting during the first 24 h after strabismus surgery: a prospective, randomised, double-blind study.

CONTEXT

Strabismus surgery is one of the most common ophthalmic surgical procedures in children and is associated with significant postoperative nausea and vomiting (PONV).

OBJECTIVE

We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.

DESIGN

Prospective, placebo-controlled, randomised double-blind study.

SETTING

University hospital.

PATIENTS

Ninety children, between 2 and 14 years scheduled for strabismus surgery, were recruited. Eighty-six completed the study.

INTERVENTIONS

After induction of anaesthesia, intravenous dexamethasone 0.1 mg kg was administered to all. The patients were enrolled to receive either intravenous physiological saline (group S) or paracetamol 15 mg kg (group P).

MAIN OUTCOME MEASURE

Incidence of PONV in the first 24 h postoperatively.

RESULTS

General and clinical characteristics of the children were similar in both groups. PONV during the first 24 h was significantly higher in group S in comparison with group P (group S vs. group P, 33 vs. 14.6%, respectively, P = 0.038 for nausea; 24.4 vs. 7.3%, respectively, P = 0.030 for vomiting). The number of analgesic administrations during the first 24 h was higher in group S compared with group P (1.31 ± 0.85 and 0.73 ± 0.6, respectively, P = 0.001). The repeat number of postoperative analgesic administrations was significantly different between groups during the first 24 h (P = 0.005), but during 24-48 h was not significant.

CONCLUSION

Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.