Rokas Antonis
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Curr Protoc Mol Biol. 2011 Oct;Chapter 19:Unit19.11. doi: 10.1002/0471142727.mb1911s96.
Phylogenetic analysis is the study of evolutionary relationships among molecules, phenotypes, and organisms. In the context of protein sequence data, phylogenetic analysis is one of the cornerstones of comparative sequence analysis and has many applications in the study of protein evolution and function. This unit provides a brief review of the principles of phylogenetic analysis and describes several different standard phylogenetic analyses of protein sequence data using the RAXML (Randomized Axelerated Maximum Likelihood) Program.
系统发育分析是对分子、表型和生物体之间进化关系的研究。在蛋白质序列数据的背景下，系统发育分析是比较序列分析的基石之一，在蛋白质进化和功能研究中有许多应用。本单元简要回顾了系统发育分析的原理，并描述了使用RAXML（随机加速最大似然法）程序对蛋白质序列数据进行的几种不同的标准系统发育分析。
