Piva Marta Rabello, Santos Thiago de Santana, Martins Filho Paulo Ricardo Saquete, Kumar Paulo Nand, Souza Liane Maciel Almeida, Silva Luiz Carlos Ferreira da
Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.
An Bras Dermatol. 2011 Jul-Aug;86(4):779-83. doi: 10.1590/s0365-05962011000400025.
Inverted Schneiderian papilloma (ISP) is a neoplasm of epithelial lining origin which arises in the respiratory mucosa that lines the nasal cavity and paranasal sinuses. The inverted Schneiderian papilloma frequently appears as a unilateral lesion in the nasal septum and extends secondarily to the nasal and paranasal sinuses. This paper reports an unusual case of this pathology with involvement of the oral cavity in a 61-year-old white man. Clinical evaluation revealed a vegetating mass in the alveolar ridge of the right maxilla that had been present for approximately 4 months. After radiographic evaluation, involvement of the maxillary sinus was detected. Microscopic evaluation, in situ hybridization and immunohistochemical analysis of the specimen led to a diagnosis of ISP moderate dysplasia associated with HPV infection.
内翻性乳头状瘤（ISP）是一种起源于上皮衬里的肿瘤，发生于鼻腔和鼻窦内衬的呼吸道黏膜。内翻性乳头状瘤常表现为鼻中隔的单侧病变，并继发累及鼻腔和鼻窦。本文报道了一名61岁白人男性患此病并累及口腔的罕见病例。临床评估发现右侧上颌牙槽嵴有一个赘生物，已存在约4个月。经影像学评估，发现上颌窦受累。对标本进行显微镜评估、原位杂交和免疫组化分析后，诊断为与HPV感染相关的中度发育异常内翻性乳头状瘤。
