Uchida Masaya, Fujita Tomoki, Okamoto Kohtaro, Ueda Masayo, Ushijima Chihisa, Dejima Kenji
Department of Otolaryngology, Kyoto Second Red Cross Hospital, Kyoto.
Nihon Jibiinkoka Gakkai Kaiho. 2011 Sep;114(9):768-73. doi: 10.3950/jibiinkoka.114.768.
Unlike Schneiderian papilloma, a widespread benign epithelial neoplasm arising in the sinonasal tract mucosa of the nasal cavity, paranasal sinus, trachea, and larynx, middle-ear Schneiderian papilloma is extremely rare. We report a case of recurrent Schneiderian papilloma spreading to the bilateral middle ear and right paranasal sinus, and eventually causing cerebellar complications. A-52-year old woman seen for episodes of inarticulateness was first, found to have middle right ear and right ethmoid papilloma, that occurred thereafter is the middle left ear. This bilateral middle-ear papilloma is, to our knowledge, the only case reported thus far, and fell into a low-risk malignant formation group based on HPV-DNA testing. Given previous cases, we concluded that ours warranted meticulous follow-up because recurrence and malignancy are more common in multiple-site middle-ear papilloma as in our case rather than papilloma of the middle ear alone.
与鼻腔、鼻窦、气管和喉部鼻窦黏膜中广泛存在的良性上皮性肿瘤——鼻内翻性乳头状瘤不同，中耳鼻内翻性乳头状瘤极为罕见。我们报告一例复发性鼻内翻性乳头状瘤，其扩散至双侧中耳和右侧鼻窦，最终引发小脑并发症。一名52岁女性因言语不清发作前来就诊，最初发现右中耳和右筛窦有乳头状瘤，随后左中耳也出现了。据我们所知，这种双侧中耳乳头状瘤是迄今为止唯一报告的病例，根据人乳头瘤病毒（HPV）DNA检测，其属于低风险恶性病变组。鉴于既往病例，我们得出结论，我们的病例需要密切随访，因为多部位中耳乳头状瘤（如我们的病例）比单纯中耳乳头状瘤更易复发和恶变。
