Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Diabetologia. 2012 Jan;55(1):88-93. doi: 10.1007/s00125-011-2336-9. Epub 2011 Oct 11.
AIMS/HYPOTHESIS: The Di@bet.es Study is the first national study in Spain to examine the prevalence of diabetes and impaired glucose regulation.
A population-based, cross-sectional, cluster sampling study was carried out, with target population being the entire Spanish population. Five thousand and seventy-two participants in 100 clusters (health centres or the equivalent in each region) were randomly selected with a probability proportional to population size. Participation rate was 55.8%. Study variables were a clinical and demographic structured survey, lifestyle survey, physical examination (weight, height, BMI, waist and hip circumference, blood pressure) and OGTT (75 g).
Almost 30% of the study population had some carbohydrate disturbance. The overall prevalence of diabetes mellitus adjusted for age and sex was 13.8% (95% CI 12.8, 14.7%), of which about half had unknown diabetes: 6.0% (95% CI 5.4, 6.7%). The age- and sex-adjusted prevalence rates of isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT) and combined IFG-IGT were 3.4% (95% CI 2.9, 4.0%), 9.2% (95% CI 8.2, 10.2%) and 2.2% (95% CI 1.7, 2.7%), respectively. The prevalence of diabetes and impaired glucose regulation increased significantly with age (p < 0.0001), and was higher in men than in women (p < 0.001).
CONCLUSIONS/INTERPRETATION: The Di@bet.es Study shows, for the first time, the prevalence rates of diabetes and impaired glucose regulation in a representative sample of the Spanish population.
目的/假设：Di@bet.es 研究是西班牙首次对糖尿病和糖调节受损的流行情况进行的全国性研究。
开展了一项基于人群的、横断面的、聚类抽样研究，目标人群为西班牙全部人口。采用与人口规模成正比的概率，在每个地区的 100 个集群（卫生中心或同等机构）中随机选择了 5072 名参与者。参与率为 55.8%。研究变量包括临床和人口统计学的结构化调查、生活方式调查、体格检查（体重、身高、BMI、腰围和臀围、血压）和 OGTT（75g）。
近 30%的研究人群存在某种碳水化合物紊乱。经年龄和性别调整后的糖尿病总患病率为 13.8%（95%CI 12.8，14.7%），其中约一半为未知糖尿病：6.0%（95%CI 5.4，6.7%）。经年龄和性别调整后的单纯空腹血糖受损（IFG）、单纯糖耐量受损（IGT）和 IFG-IGT 合并患病率分别为 3.4%（95%CI 2.9，4.0%）、9.2%（95%CI 8.2，10.2%）和 2.2%（95%CI 1.7，2.7%）。糖尿病和糖调节受损的患病率随年龄显著增加（p<0.0001），且男性高于女性（p<0.001）。
结论/解释：Di@bet.es 研究首次在西班牙代表性人群样本中显示了糖尿病和糖调节受损的患病率。
