Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, WI, USA.
J Infect Dis. 2011 Nov;204 Suppl 3(Suppl 3):S953-6. doi: 10.1093/infdis/jir325.
Type I interferon (IFN) signaling is mediated through several signaling pathways, including the Janus kinase and signal transducer and activator (JAK-STAT) and p38 mitogen-activated protein (MAP) kinase pathways. The VP24 protein of Ebolavirus is an IFN antagonist, blocking type I IFN signaling through the JAK-STAT pathway. Here, we show that, in 293 cells, VP24 also interferes with the p38 MAP kinase pathway by blocking IFN-β-stimulated phosphorylation of p38-α. Similar inhibition was not observed in HeLa cells, suggesting cell type-specific differences in signal transduction.
I 型干扰素（IFN）信号转导是通过几条信号通路介导的，包括 Janus 激酶和信号转导及转录激活因子（JAK-STAT）和 p38 丝裂原活化蛋白（MAP）激酶通路。埃博拉病毒的 VP24 蛋白是一种 IFN 拮抗剂，通过 JAK-STAT 通路阻断 I 型 IFN 信号转导。在这里，我们表明，在 293 细胞中，VP24 还通过阻断 IFN-β 刺激的 p38-α磷酸化来干扰 p38 MAP 激酶通路。在 HeLa 细胞中未观察到类似的抑制作用，这表明在信号转导方面存在细胞类型特异性差异。
