Tarallo Mauro, Cigna Emanuele, Fino Pasquale, Sorvillo Valentina, Scuderi Nicolò
Department of Dermatology and Plastic, University of Rome Sapienza, Policlinico Umberto I, Rome, Italy.
Ann Ital Chir. 2011 Sep-Oct;82(5):389-94.
Nonmelanoma skin cancer (NMSC) is the most common cancer in the world with an incidence 18-20 times greater than that of malignant melanoma. Basal cell carcinoma, which probably arises from immature pluripotential cells, is the most common malignant tumor of the skin in Caucasian. It occurs mostly on sun-exposed areas such as neck and face. MATERIAL OR STUDY: We performed a retrospective study of 327 consecutive patients, diagnosed for metatypical basal cell carcinoma. Tumors were analyzed and measured from the surgeon, excision margins were marked on the basis of palpable or visual alteration of the burden. The minimum surgical margin was equal to the short axis of the ellipse. Therapy was made according to guidelines.
A relevant difference came out between two genders. 213 Males (65%) were affected in comparison with only 114 females (35%). Concerning areas affected, first is cervico-facial area with a prevalence of 220 cases (67.3%), second trunk 33 cases (10.1%), third other areas 29 cases (8.86%), fourth limbs 32 cases (9.80%), fifth scalp with 13 cases (4%).
Diagnosis is based on histological analysis. Histologically MTC is divided into two subtypes: intermediated and mixed. In the intermediate form transitional zones and tumor islets are found together, thus combining features of BCC and SCC In mixed subtype typical basal cells coexist with areas of conglomerated squamous cells, squamous pearls could be present.
非黑色素瘤皮肤癌（NMSC）是世界上最常见的癌症，其发病率比恶性黑色素瘤高18 - 20倍。基底细胞癌可能起源于未成熟的多能细胞，是白种人中最常见的皮肤恶性肿瘤。它大多发生在颈部和面部等暴露于阳光的部位。材料或研究：我们对327例连续诊断为异型基底细胞癌的患者进行了回顾性研究。从外科医生处获取肿瘤并进行分析和测量，根据可触及或可见的肿物改变标记切除边缘。最小手术切缘等于椭圆的短轴。治疗按照指南进行。
两性之间出现了显著差异。213名男性（65%）患病，而女性仅114名（35%）。关于受累部位，首先是颈面部区域，有220例（67.3%），其次是躯干33例（10.1%），第三是其他区域29例（8.86%），第四是四肢32例（9.80%），第五是头皮13例（4%）。
诊断基于组织学分析。组织学上，MTC分为两种亚型：中间型和混合型。在中间型中，过渡区和肿瘤小岛同时存在，从而兼具基底细胞癌和鳞状细胞癌的特征。在混合型中，典型的基底细胞与聚集的鳞状细胞区域共存，可能存在鳞状上皮珠。
