Kazantseva I A, Khlebnikova A N, Babaev V R, Fager G
Arkh Patol. 1994 Jul-Aug;56(4):35-8.
Using avidin-biotin, immunoperoxidase techniques and antibodies to proliferating cell nuclear antigen (PC10), 32 cases of primary basal cell carcinoma (BCC), 10 cases of recurrent BCC and 8 cases of metatypical carcinoma (MTC) of the skin were studied. The majority of cases of primary BCC had low level of cell proliferative activity, whereas high cell proliferative index was found only in 7 cases. Recurrent BCC as well as MTC exhibited high level of cell proliferative index that 3-4 times exceeded the same index of primary BCC. BCC had either uniform or regional distribution of proliferative cells. Tumors with regional distribution of proliferative cells are characterized by a low level of proliferation. The revealed difference in cell proliferation between primary BCC, recurrent BCC and MTC may be valuable criterion for detecting the degree of tumor malignancy.
运用抗生物素蛋白-生物素、免疫过氧化物酶技术以及抗增殖细胞核抗原（PC10）抗体，对32例原发性基底细胞癌（BCC）、10例复发性BCC和8例皮肤化生型癌（MTC）进行了研究。大多数原发性BCC病例的细胞增殖活性水平较低，而仅在7例中发现高细胞增殖指数。复发性BCC以及MTC均表现出高细胞增殖指数，该指数比原发性BCC的同一指数高出3至4倍。BCC的增殖细胞分布均匀或呈区域性。增殖细胞呈区域性分布的肿瘤具有低增殖水平的特征。原发性BCC、复发性BCC和MTC之间所揭示的细胞增殖差异可能是检测肿瘤恶性程度的有价值标准。
