Division of Neurology, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, 350 West Thomas Street, Phoenix, AZ 85213, USA.
Nat Rev Neurol. 2011 Oct 11;7(11):631-8. doi: 10.1038/nrneurol.2011.151.
Insights into the mechanisms of amyotrophic lateral sclerosis (ALS) have relied predominantly on the study of postmortem tissue. Modern technology has improved the ability of scientists to probe effectively the underlying biology of ALS by examination of genomic, proteomic and physiological changes in patients, as well as to monitor functional and structural changes in patients over the course of disease. While effective treatments for ALS are lacking, the discovery of biomarkers for this disease offers clinicians tools for rapid diagnosis, improved ways to monitor disease progression, and insights into the pathophysiology of sporadic ALS. The ultimate aim is to broaden the therapeutic options for patients with this disease.
对肌萎缩侧索硬化症 (ALS) 机制的深入了解主要依赖于对尸检组织的研究。现代技术提高了科学家通过检查患者的基因组、蛋白质组和生理变化，以及监测患者在疾病过程中的功能和结构变化，来有效探究 ALS 潜在生物学的能力。虽然 ALS 缺乏有效的治疗方法，但该疾病生物标志物的发现为临床医生提供了快速诊断的工具，改善了监测疾病进展的方法，并深入了解了散发性 ALS 的病理生理学。最终目的是为患有这种疾病的患者拓宽治疗选择。
