Lanata C F, Tafur C, Benavente L, Gotuzzo E, Carrillo C
Department of Public Health, Peruvian University Cayetano Heredia, Lima.
Bull Pan Am Health Organ. 1990;24(2):177-82.
The work described here sought to assess the merits of using an indirect hemagglutination test employing highly purified Vi antigen to screen a high-risk population for chronic S. typhi carriers in Lima, Peru. A total of 1,931 female food handlers over 30 years old were enrolled in the study. Indirect hemagglutination tests performed on these subjects' sera, taking a titer of 1:40 or more as positive, yielded 29 positive results. Subsequent bacteriologic testing performed on 26 of these 29 subjects identified four (15%) as S. typhi carriers. The procedure had a sensitivity of 79%, indicating that the prevalence of S. typhi carriers among the population studied was on the order of 262 per 100,000. It appears that Vi serology employing highly purified Vi antigen offers a practical and cost-effective way of screening for S. typhi carriers in both endemic and nonendemic typhoid fever areas.
本文所述工作旨在评估使用采用高纯度Vi抗原的间接血凝试验，对秘鲁利马的高危人群进行慢性伤寒杆菌携带者筛查的优点。共有1931名30岁以上的女性食品处理人员参与了该研究。对这些受试者的血清进行间接血凝试验，以滴度1:40及以上为阳性，结果有29个阳性。随后对这29名受试者中的26名进行细菌学检测，确定其中4名（15%）为伤寒杆菌携带者。该方法的灵敏度为79%，这表明在所研究人群中伤寒杆菌携带者的患病率约为每10万人262例。看来采用高纯度Vi抗原的Vi血清学检测为在伤寒流行区和非流行区筛查伤寒杆菌携带者提供了一种实用且经济高效的方法。
