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长链脂质是巨噬细胞先天识别海藻糖二酯所必需的。

Long-chain lipids are required for the innate immune recognition of trehalose diesters by macrophages.

机构信息

Malaghan Institute of Medical Research, Wellington 6242, New Zealand.

出版信息

Chembiochem. 2011 Nov 25;12(17):2572-6. doi: 10.1002/cbic.201100451. Epub 2011 Oct 11.

DOI:10.1002/cbic.201100451
PMID:21990105
Abstract

Going to any length? Trehalose diesters of various chain lengths have been synthesised in order to determine the effect of lipid length on innate immune recognition, as determined by NO and cytokine production by macrophages. In this work, we show that longer lipids (C(20) -C(26)) are required for macrophage activation, with C(22) giving optimal activity.

摘要

为了确定脂链长度对巨噬细胞固有免疫识别的影响，合成了不同链长的海藻糖二酯。在这项工作中，我们表明较长的脂质（C（20）-C（26））对于巨噬细胞的激活是必需的，其中 C（22）具有最佳的活性。

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