L-舒必利抗抑郁作用的可能机制。
Possible mechanism of antidepressant effect of L-sulpiride.
作者信息
Serra G, Forgione A, D'Aquila P S, Collu M, Fratta W, Gessa G L
机构信息
B. B. Brodie Department of Neurosciences, University of Cagliari, Italy.
出版信息
Clin Neuropharmacol. 1990;13 Suppl 1:S76-83. doi: 10.1097/00002826-199001001-00009.
Abstract
L-Sulpiride is a dopamine (DA)-receptor blocker that acts as an antidepressant at low doses. We have reviewed evidence suggesting that the antidepressant effect of L-sulpiride may depend on the activation of DA transmission secondary to the blockade of DA autoreceptors.
摘要
左旋舒必利是一种多巴胺（DA）受体阻滞剂，在低剂量时可作为一种抗抑郁药。我们回顾了相关证据，这些证据表明左旋舒必利的抗抑郁作用可能依赖于在多巴胺自身受体被阻断后多巴胺传递的激活。
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