用于预防的艾滋病治疗的致命弱点：接受抗逆转录病毒疗法的艾滋病毒/艾滋病感染者中性传播合并感染的病史。
The Achilles' Heel of HIV Treatment for Prevention: History of Sexually Transmitted Coinfections among People Living with HIV/AIDS Receiving Antiretroviral Therapies.
作者信息
Kalichman Seth C, Cherry Chauncey, White Denise, Jones Mich'l, Kalichman Moira
机构信息
1Department of Psychology, University of Connecticut, Storrs, CT, USA.
出版信息
J Int Assoc Physicians AIDS Care (Chic). 2011 Nov-Dec;10(6):365-72. doi: 10.1177/1545109711418120. Epub 2011 Oct 11.
BACKGROUND
Antiretroviral therapies (ARTs) offer promising new avenues for HIV prevention. Unfortunately, people infected with HIV who have co-occurring sexually transmitted infections (STIs) are more infectious than suggested by the amount of virus in their peripheral blood. We examined the history of sexually transmitted coinfections in people living with HIV.
METHODS
People living with HIV/AIDS completed confidential computerized interviews that assessed history of STI, sexual behaviors, and STI knowledge.
RESULTS
Among 414 men and 156 women currently receiving ART, 53% had been diagnosed with at least 1 STI since testing HIV positive; 24% women, 19% men, and 11% transgender persons had been diagnosed with an STI in the past year. History of STI was associated with younger age, greater STI knowledge, substance use, and ART nonadherence.
CONCLUSIONS
Aggressive strategies for detecting and treating STI in people receiving ART will be necessary to achieve protective benefits.
背景
抗逆转录病毒疗法（ARTs）为艾滋病预防提供了新的有效途径。不幸的是，同时感染性传播感染（STIs）的艾滋病毒感染者比其外周血中病毒量所显示的更具传染性。我们研究了艾滋病毒感染者的性传播合并感染史。
方法
艾滋病毒/艾滋病感染者完成了保密的计算机化访谈，评估性传播感染史、性行为和性传播感染知识。
结果
在目前接受抗逆转录病毒治疗的414名男性和156名女性中，53%自艾滋病毒检测呈阳性以来被诊断出至少患有一种性传播感染；在过去一年中，24%的女性、19%的男性和11%的跨性别者被诊断出患有性传播感染。性传播感染史与年龄较小、性传播感染知识较多、药物使用和抗逆转录病毒治疗不依从有关。
结论
为了实现保护效益，有必要采取积极策略来检测和治疗接受抗逆转录病毒治疗者的性传播感染。
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