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[亚油酸及其自由基氧化产物对琥珀酸脱氢酶的影响]

[Effect of linoleic acid and products of its free radical oxidation on succinate dehydrogenase].

作者信息

Turovetskiĭ V B, Sepetov N F, Danilov V S

出版信息

Biofizika. 1979 Jan-Feb;24(1):72-6.

PMID:219908
Abstract

Effects of linoleic acid and its oxidation products (with 75--80% content of hydroperoxide) on isolated succinate dehydrogenase were studied by means of spectrophotometry and ESR-spectroscopy. It was shown that unlike the unoxidized acid, low concentrations of its oxidation products increased catalytic activity, while its high concentrations of its oxidation products increased catalytic activity, while its high concentrations brought about a decrease of SH-group content and the amplitude of ESR signal of reduced nonheme iron in the enzyme.

摘要

通过分光光度法和电子自旋共振光谱法研究了亚油酸及其氧化产物(氢过氧化物含量为75 - 80%)对分离出的琥珀酸脱氢酶的影响。结果表明,与未氧化的酸不同,低浓度的氧化产物会提高催化活性,而高浓度的氧化产物则会导致酶中巯基含量降低以及还原态非血红素铁的电子自旋共振信号幅度减小,同时高浓度的氧化产物也会提高催化活性。

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