Lakshmi R T S, Priyanka T, Meenakshi J, Mathangi K R, Jeyaraman V, Babu M
Central Leather Research Institute, Chennai, India.
Ann Burns Fire Disasters. 2011 Mar 31;24(1):24-9.
Nitric oxide (NO) is an important signal molecule in many types of cells and tissues. Efficiently balanced NO production was noted to play an important role in the healing of burns. Inducible nitric oxygen synthase (iNOS) is responsible for the discontinuous synthesis of high amounts of NO. Dysregulation of nitric oxygen synthase (NOS) activity has been associated with multiple organ failure in burn patients and may therefore represent a novel therapeutic target in such circumstances. Heparin and low molecular weight heparin (LMWH) derivatives may offer therapeutic benefit for inflammatory diseases, whereas NO plays a protagonist role. Burn injury in humans has been associated with a significant increase in NO(2)/NO(3) (nitrite/nitrate) plasma levels. In this prospective study burn patients were treated with and without LMWH to provide evidence that LMWH has NOS-reducing activity. This was proved by colorimetric and immunohistological studies. There was a significantly different NOS activity between the treated and the control group and our results suggest that LMWH was more effective in the treatment of burn patients through iNOS inhibition. Treatment with LMWH was initiated within 6 h post-burn.
一氧化氮（NO）是多种细胞和组织中的重要信号分子。研究发现，有效平衡的NO生成在烧伤愈合中起重要作用。诱导型一氧化氮合酶（iNOS）负责大量NO的间断性合成。一氧化氮合酶（NOS）活性失调与烧伤患者的多器官功能衰竭有关，因此在这种情况下可能是一个新的治疗靶点。肝素和低分子量肝素（LMWH）衍生物可能对炎症性疾病有治疗益处，而NO起主要作用。人类烧伤与血浆中NO(2)/NO(3)（亚硝酸盐/硝酸盐）水平显著升高有关。在这项前瞻性研究中，对烧伤患者进行了使用和不使用LMWH的治疗，以证明LMWH具有降低NOS活性的作用。这通过比色法和免疫组织学研究得到了证实。治疗组和对照组之间的NOS活性存在显著差异，我们的结果表明，LMWH通过抑制iNOS在烧伤患者治疗中更有效。LMWH治疗在烧伤后6小时内开始。
