Gökçen Başaranoğlu, Gökhan Teker M, Kerem Erkalp, Haluk Ozdemir, Cemil Yilmazli, Leyla Saidoğlu
Department ofAnesthesia and Reanimation, Vakif Gureba Education and Teaching Hospital, Istanbul, Turkey.
Middle East J Anaesthesiol. 2011 Feb;21(1):35-8.
We have compared the effect of low dose rocuronium on intraocular pressure (IOP) in larygeal mask airway usage during induction of anesthesia using propofol and fentanyl, in a randomized, double-blind study.
We studied 30 patients randomly allocated to one of two groups. Anesthesia was induced with fentanyl 1 mg kg(-1) and propofol 2 mg kg(-1) until loss of eyelash reflex. This was followed by rocuronium 0,3 mg kg(-1) (group R, n = 15) and normal saline (group S, n = 15). IOP was measured with Schiotz tonometry device preoperatively (IOP(pre)) and after propofol infection (IOP(0)) and immediately after LMA insertion (IOP(1)), 1. (IOP(2)), 2. (IOP(3)), 3. (IOP(4)), 4. (IOP(5)) and 15. (IOP(15)) minutes after laryngeal mask airway (LMA) insertion and after extubation (IOP(ext)). The collected data were heart rate (HR), oxygen saturation (SpO(2)), end-tidal carbon-dioxide pressure (ETCO(2)) and mean arterial pressure (MAP).
After LMA insertion significant decrease was found in IOP in both groups. No significant difference was found between groups.
Although there have been reports that LMA insertion minimally increases IOP, in our study, by using low dose rocuronium and LMA there was a decrease in IOP.
在一项随机双盲研究中，我们比较了低剂量罗库溴铵对使用喉罩气道并采用丙泊酚和芬太尼诱导麻醉期间眼压（IOP）的影响。
我们研究了30例患者，随机分为两组。用1mg/kg（-1）芬太尼和2mg/kg（-1）丙泊酚诱导麻醉，直至睫毛反射消失。随后，一组给予0.3mg/kg（-1）罗库溴铵（R组，n = 15），另一组给予生理盐水（S组，n = 15）。术前（IOP（pre））、丙泊酚注射后（IOP（0））、喉罩插入后即刻（IOP（1））、1分钟后（IOP（2））、2分钟后（IOP（3））、3分钟后（IOP（4））、4分钟后（IOP（5））、15分钟后（IOP（15））以及拔管后（IOP（ext）），使用Schiotz眼压计测量眼压。收集的数据包括心率（HR）、血氧饱和度（SpO（2））、呼气末二氧化碳分压（ETCO（2））和平均动脉压（MAP）。
两组在喉罩插入后眼压均显著下降。两组之间未发现显著差异。
尽管有报道称喉罩插入对眼压的升高作用极小，但在我们的研究中，使用低剂量罗库溴铵和喉罩可使眼压降低。
