George Washington University Hospital-The GW Spine & Pain Center, George Washington Medical Center, 2131 K. Street, N. W., Washington, DC 20037, USA.
Neuromodulation. 2011 May-Jun;14(3):249-52; discussion 252. doi: 10.1111/j.1525-1403.2011.00356.x. Epub 2011 Apr 15.
The objective of this study is to present a novel approach to the treatment of thoracic radiculitis following Brown-Sequard syndrome with peripheral nerve field stimulation (PNFS). Furthermore, we endeavor to discuss the role of PNFS in the management of refractory neuropathic pain conditions including post-traumatic and post-surgical neuropathy particularly with regards to the post-surgical spine.
Presented is a 57-year-old man with history of thoracic microdiscectomy resulting in Brown-Sequard syndrome presented with chronic post-operative thoracic radicular pain radiating to the abdomen, refractory to conservative management. The patient underwent three intercostal nerve blocks from T7 to T9 with transient symptomatic relief. The patient's options were limited to chemomodulation, neuromodulation, or selective intercostal nerve surgical neurectomy. He subsequently underwent a PNFS trial and reported >75% pain reduction. Permanent percutaneous PNFS electrodes were implanted subcutaneously over the right T7 and T9 intercostal nerves and replicated the trial results.
Neuromodulation produced pain relief with >90% improvement in pain compared with baseline both during the trial and following permanent implantation of the PNFS system.
Chronic radicular pain may be difficult to manage in the post-surgical patient and often requires the use of multiple therapeutic modalities. In this case, we successfully utilized PNFS as it demonstrated greater technical feasibility when compared with dorsal column stimulation and repeat surgery; therefore, it may be considered for the management of post-surgical neuropathy. Further controlled studies are needed to evaluate the efficacy of PNFS as a treatment option.
本研究旨在提出一种治疗 Brown-Sequard 综合征后胸神经根炎的新方法,即外周神经场刺激(PNFS)。此外,我们还致力于探讨 PNFS 在管理难治性神经性疼痛疾病中的作用,包括创伤后和手术后神经病变,特别是与手术后脊柱相关的疾病。
介绍一位 57 岁男性,曾因胸椎间盘微切除术导致 Brown-Sequard 综合征,术后出现慢性胸神经根痛,放射至腹部,经保守治疗无效。患者接受了 T7 至 T9 肋间神经的 3 次肋间神经阻滞,症状暂时缓解。患者的选择有限,包括化学调节、神经调节或选择性肋间神经手术神经切除术。随后,他进行了 PNFS 试验,报告疼痛减轻>75%。永久性经皮 PNFS 电极皮下植入右侧 T7 和 T9 肋间神经,复制了试验结果。
神经调节产生了疼痛缓解,与基线相比,疼痛改善>90%,无论是在试验期间还是在永久性植入 PNFS 系统后。
手术后患者的慢性根性疼痛可能难以管理,通常需要多种治疗方式。在这种情况下,我们成功地使用了 PNFS,因为与背柱刺激和重复手术相比,它具有更高的技术可行性;因此,它可能被考虑用于治疗手术后神经病变。需要进一步的对照研究来评估 PNFS 作为一种治疗选择的疗效。